Gene interactions and pathways from curated databases and text-mining

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NOTCH2 — TLR2

Text-mined interactions from Literome

Hu et al., Immunity 2008 : This Hes1- and Hey1 mediated feedback inhibitory loop was abrogated by interferon-gamma (IFN-gamma), which blocked TLR induced activation of canonical Notch target genes by inhibiting Notch2 signaling and downstream transcription
Zhang et al., J Biol Chem 2012 (Inflammation...) : It is widely accepted that TLR signaling can activate Notch pathway ; however, whether full activation of Notch signaling can feedback modulate TLR signaling pathway so as to control inflammation response remains unclear