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LEP — NOX1

Text-mined interactions from Literome

Li et al., Diabetes 2005 : Overall, these results demonstrate that leptin induced HASMC proliferation and MMP-2 expression through a PKC dependent activation of NAD ( P ) H oxidase with subsequent activation of the ERK1/2/NF-kappaB pathways and that therapeutic metformin concentrations effectively inhibit these biological effects
De Minicis et al., Hepatology 2008 (Disease Models, Animal...) : Leptin induced NADPH oxidase acts downstream of JAK activation but is independent of STAT3
Fortuño et al., J Hypertens 2010 (Atherosclerosis...) : In-vitro studies showed that leptin induced NADPH oxidase activation ... Inhibition of the leptin induced NADPH oxidase activity by wortmannin and bisindolyl maleimide suggested a direct involvement of the phosphatidylinositol 3-kinase and protein kinase C pathways, respectively ... Finally, leptin induced NADPH oxidase activation promoted macrophage proliferation
Chatterjee et al., J Hepatol 2013 (Disease Models, Animal...) : These results, for the first time, suggest that leptin action in macrophages of the steatotic liver, through induction of iNOS and NADPH oxidase , causes peroxynitrite mediated oxidative stress thus activating Kupffer cells