Gene interactions and pathways from curated databases and text-mining

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AKT2 — NPPA

Text-mined interactions from Literome

Kook et al., Am J Physiol Heart Circ Physiol 2003 : ANP increased the expression of phospho-Akt and of phospho-ERK1/2 within 1.5 h
Ladetzki-Baehs et al., Endocrinology 2007 (Inflammation) : ANP also reduces Akt activation upon lipopolysaccharide injection
You et al., Endocrinology 2009 : ANP and 8-Br-cGMP stimulated the phosphorylation of Akt and Foxo1a in INS-1E cells and islets, and LY294002 inhibited these responses ... These data support the conclusion that the activation of Akt by ANP or 8-Br-cGMP promotes cyclin D2, PDX-1, and glucokinase transcription by phosphorylating and restricting Foxo1a activity
Sauvé et al., Diabetes 2010 (Diabetes Mellitus, Experimental...) : Increased cardiac expression of phosphorylated AKT ( pAKT ), pGSK3beta, and atrial natriuretic peptide (ANP) was detected in the nonischemic Dpp4 ( -/- ) heart, and HO-1, ANP , and pGSK3beta proteins were induced in nonischemic hearts from diabetic mice treated with sitagliptin or metformin
O'Tierney et al., J Physiol 2010 : Ang II-stimulated ERK and Akt phosphorylation was inhibited by 100 nm ANP
Nesher et al., Can J Physiol Pharmacol 2012 : Furthermore, ouabain ( 50 nmol/L ) or ANP ( 10 nmol/L ) alone induced Akt activation in cardiomyocytes ... However, ANP blocked ouabain induced Akt activation