Gene interactions and pathways from curated databases and text-mining

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MAPK1 — NTF3

Text-mined interactions from Literome

Gottschalk et al., Learn Mem 1999 : Neurotrophin-3 (NT-3) , a close relative of BDNF, did not activate MAPK or PI3K and had no effect on synaptic fatigue in the neonatal hippocampus
Vesa et al., J Biol Chem 2000 : p75 did not effect extracellular signal regulated kinase 2 tyrosine phosphorylation in response to brain derived neurotrophic factor , neurotrophin 3, or neurotrophin 4/5
Liot et al., Exp Neurol 2004 (MAP Kinase Signaling System) : First, we showed that, in cultured cortical neurons, NT-3 could promote extracellular signal regulated protein kinase/mitogen activated protein kinase ( ERK/MAPK ) and phosphatidylinositol-3' (PI-3) kinase/Akt phosphorylation
Shi et al., Cell Signal 2006 : Dok5 is substrate of TrkB and TrkC receptors and involved in neurotrophin induced MAPK activation
Je et al., J Cell Biol 2006 : Genetic and imaging experiments indicate that the small GTPase Rap1, but not Ras, acts upstream of MAPK activation by NT-3
Shinoda et al., J Neurosci 2007 : Knockdown of DISC1 also inhibited the neurotrophin-3 (NT-3) induced phosphorylation of ERK-1/2 at the distal part of axons and inhibited NT-3 induced axon elongation
Lim et al., Biochem Biophys Res Commun 2007 (MAP Kinase Signaling System) : However, the mechanisms by which neurotrophin-3 promotes prolonged Akt/MAPK signaling at an early stage are not well understood
Moubarak et al., J Neurosci 2010 : Altogether, we uncover a new role for FLIP-L as an unexpected critical player in neurotrophin induced mitogen activated protein kinase/ERK- and NF-kappaB mediated control of neurite growth in developing neurons
White et al., Br J Cancer 2010 (Sarcoma, Ewing) : Sustained p38 ( MAPK ) phosphorylation upregulates p75 neurotrophin ( p75 ( NTR ) ) and induces apoptosis in Ewing 's sarcoma family of tumours ( ESFT )
Ivanov et al., Oncogene 2013 (Carcinoma, Adenoid Cystic...) : NT-3 stimulation of U2OS cells with ectopic TrkC expression triggered TrkC phosphorylation and resulted in Ras, Erk 1/2 and Akt activation, as well as VEGFR1 phosphorylation
Guiton et al., J Biol Chem 1995 : In cells expressing full-length TrkC, neurotrophin-3 promoted a sustained activation of mitogen activated protein kinase ; TrkC containing kinase inserts only mediated transient activation of mitogen activated protein kinase ... In cells expressing full-length TrkC, neurotrophin-3 promoted a sustained activation of mitogen activated protein kinase ; TrkC containing kinase inserts only mediated transient activation of mitogen activated protein kinase
Cohen et al., J Neurosci 1996 : NGF and NT-3 both induced the phosphorylation of mitogen activated protein kinase ( MAPK ) in OLPs and in OLs
Kumar et al., J Neurosci Res 1998 : Furthermore, NT-3 mediated activation of p21ras and mitogen activated protein kinase ( MAPK ), extracellular signal regulated protein kinase2 ( ERK2 ), were also observed in the progenitor OL cells