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MAPK1 — NTF3
Text-mined interactions from Literome
Gottschalk et al., Learn Mem 1999
:
Neurotrophin-3 (NT-3) , a close relative of BDNF, did not
activate MAPK or PI3K and had no effect on synaptic fatigue in the neonatal hippocampus
Vesa et al., J Biol Chem 2000
:
p75 did not effect
extracellular signal regulated kinase 2 tyrosine phosphorylation in
response to brain derived
neurotrophic factor , neurotrophin 3, or neurotrophin 4/5
Liot et al., Exp Neurol 2004
(MAP Kinase Signaling System) :
First, we showed that, in cultured cortical neurons,
NT-3 could
promote extracellular signal regulated protein
kinase/mitogen activated protein kinase ( ERK/MAPK ) and phosphatidylinositol-3' (PI-3) kinase/Akt phosphorylation
Shi et al., Cell Signal 2006
:
Dok5 is substrate of TrkB and TrkC receptors and involved in
neurotrophin induced
MAPK activation
Je et al., J Cell Biol 2006
:
Genetic and imaging experiments indicate that the small GTPase Rap1, but not Ras, acts upstream of
MAPK activation by
NT-3
Shinoda et al., J Neurosci 2007
:
Knockdown of DISC1 also inhibited the
neurotrophin-3 (NT-3) induced phosphorylation of
ERK-1/2 at the distal part of axons and inhibited NT-3 induced axon elongation
Lim et al., Biochem Biophys Res Commun 2007
(MAP Kinase Signaling System) :
However, the mechanisms by which
neurotrophin-3 promotes prolonged
Akt/MAPK signaling at an early stage are not well understood
Moubarak et al., J Neurosci 2010
:
Altogether, we uncover a new role for FLIP-L as an unexpected critical player in
neurotrophin induced
mitogen activated protein kinase/ERK- and NF-kappaB mediated control of neurite growth in developing neurons
White et al., Br J Cancer 2010
(Sarcoma, Ewing) :
Sustained p38 (
MAPK ) phosphorylation
upregulates p75
neurotrophin ( p75 ( NTR ) ) and induces apoptosis in Ewing 's sarcoma family of tumours ( ESFT )
Ivanov et al., Oncogene 2013
(Carcinoma, Adenoid Cystic...) :
NT-3 stimulation of U2OS cells with ectopic TrkC expression triggered TrkC phosphorylation and
resulted in Ras,
Erk 1/2 and Akt activation, as well as VEGFR1 phosphorylation
Guiton et al., J Biol Chem 1995
:
In cells expressing full-length TrkC,
neurotrophin-3 promoted a sustained activation of
mitogen activated protein kinase ; TrkC containing kinase inserts only mediated transient activation of mitogen activated protein kinase ... In cells expressing full-length TrkC,
neurotrophin-3 promoted a sustained activation of
mitogen activated protein kinase ; TrkC containing kinase inserts only mediated transient activation of mitogen activated protein kinase
Cohen et al., J Neurosci 1996
:
NGF and
NT-3 both
induced the phosphorylation of
mitogen activated protein kinase ( MAPK ) in OLPs and in OLs
Kumar et al., J Neurosci Res 1998
:
Furthermore,
NT-3 mediated activation of p21ras and
mitogen activated protein kinase ( MAPK ), extracellular signal regulated protein kinase2 ( ERK2 ), were also observed in the progenitor OL cells