Gene interactions and pathways from curated databases and text-mining

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CASP4 — NUAK1

Text-mined interactions from Literome

Suzuki et al., Oncogene 2003 (Carcinoma, Hepatocellular...) : Western blotting analysis revealed that both TRAIL and glucose starvation induced Bid cleavage and FLIP degradation following caspase 8 activation in a time dependent manner, and ARK5 overexpression clearly delayed Bid cleavage, FLIP degradation, and caspase 8 activation
Suzuki et al., Oncogene 2004 : FLIP was expressed in only ARK5 mRNA expressing cell lines, and ARK5/AS induced FLIP cleavage in a caspase-6 dependent manner ... Active ARK5 was found to phosphorylate wild-type caspase-6 in vitro, but not caspase-6/SA, and the prevented activation of caspase-6 was promoted due to its phosphorylation by active ARK5 in vitro