Gene interactions and pathways from curated databases and text-mining

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EPO — PI3

Text-mined interactions from Literome

Kubota et al., EMBO J 2001 : In K562 cells, Src associated with PI3-kinase in response to erythropoietin ... Antisense src RNA expression in K562 cells inhibited the erythropoietin induced activation of PI3-kinase and its association with erythropoietin receptor ... PP1, a selective inhibitor of the Src family, reduced erythropoietin induced tyrosine phosphorylation of erythropoietin receptor and its association with PI3-kinase in F-36P human erythroleukaemia cells
Digicaylioglu et al., Proc Natl Acad Sci U S A 2004 : The synergistic effect of EPO+IGF-I was mediated , at least in part, by activation of phosphatidylinositol 3-kinase (PI3-K)
Kadri et al., Mol Cell Biol 2005 : We report here that erythropoietin regulates the transcription of the TIMP-1 gene upon binding to its receptor in erythroid cells by triggering the activation of phosphatidylinositol 3-kinase (PI3K)/Akt