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PI3 — PTGS2

Text-mined interactions from Literome

Barry et al., J Biol Chem 1999 : In U-937 cells, MP-induced COX-2 expression and eicosanoid formation is prevented by pharmacological inhibitors of protein kinase C ( PKC ), PI 3-kinase , mitogen activated protein kinase ( MAPK ) /extracellular signal regulated kinase, and p38 kinase
Weaver et al., Gastroenterology 2001 : We investigated the regulatory role of PI 3-kinase on COX-2 expression in colonic epithelial cells ... The PI 3-kinase inhibitor wortmannin up-regulated induced COX-2 expression in a concentration dependent manner in both HT-29 and Caco-2 cells ... COX-2 is negatively regulated by PI 3-kinase ; we propose that the inhibitory effect of IL-4 and IL-13 is mediated via a PI 3-kinase dependent pathway
Ashida et al., Exp Dermatol 2003 (MAP Kinase Signaling System) : Inhibitors of MEK, p38 MAP kinase and PI3-kinase , suppressed the induction of COX-2 expression by UV
Chang et al., Mol Pharmacol 2004 : In this study, we explore the role of Ras, phosphoinositide-3-OH-kinase (PI3K) , Akt, and transcription factor nuclear factor-kappaB (NF-kappaB) in YC-1 induced COX-2 expression in A549 cells
Takeda et al., J Dermatol 2004 (Skin Neoplasms) : The PI3 kinase inhibitor LY294002 reduced COX-2 expression in HSC-5 cells and, contrary to our expectation, the phosphorylation of Akt was significantly decreased
Chen et al., Mol Biol Cell 2005 : MG132 induced DNA binding activity of C/EBPdelta, but not C/EBPbeta was regulated by p38, PI3K , Src, and protein kinase C. Small interfering RNA of C/EBPdelta suppressed COX-2 expression, further strengthening the role of C/EBPdelta in COX-2 gene transcription
Rodríguez-Barbero et al., Kidney Int 2006 : We designed studies to determine ( 1 ) whether TGF-beta1 stimulates COX-2 expression in primary HMC, ( 2 ) whether mitogen activated protein kinase ( MAPK ) and phosphatidylinositol 3-kinase (PI3K) cascades are involved in TGF-beta1 induced COX-2 expression, and ( 3 ) whether prostaglandin ( PG ) E2 synthesis is affected by TGF-beta1 and MAP kinases and PI3K activation
Liu et al., Mol Immunol 2007 : Further studies show that the triptolide mediated inhibitory effects of LPS induced activation of phosphatidylinositol-3 kinase (PI3-K)/Akt and nuclear NF-kappaB activation are involved in down-regulation of COX-2 and CCR7 expression resulting in impaired migration to secondary lymphoid organs of DC
de Oliveira et al., Glia 2008 : In contrast to other reports, LPS induced mPGES-1 synthesis was not invariably coupled to the synthesis of COX-2, since inhibition of PI-3K with LY294002 decreased mPGES-1 but increased COX-2 levels
Sun et al., Toxicol Appl Pharmacol 2008 : While investigating whether phosphatidylinositol 3 kinase (PI3K) plays a role in corticosterone ( CT ) -induced COX-2 , we found that LY294002 ( LY29 ) but not wortmannin ( WM ) attenuates CT from inducing COX-2 gene expression
Husvik et al., Eur J Oral Sci 2009 (Carcinoma, Basosquamous...) : Surprisingly, inhibition of phosphoinositide-3 kinase (PI3K) increased EGF induced COX-2 expression in the basaloid OSCC cell line ( C12 ), suggesting a PI3K controlled, inhibitory COX-2 regulating pathway
Lin et al., Int Immunopharmacol 2010 : On the other hand, PGN induced iNOS and COX-2 up-regulation were attenuated by PI3-kinase inhibitors ( LY294002 and wortmannin ), and an AKT inhibitor
Frey et al., Lab Invest 2010 (Colonic Neoplasms) : ErbB4 stimulated COX-2 induction was associated with an increase in mRNA half-life and was blocked by inhibition of Src, phosphatidylinositol (PI) 3-kinase , or epidermal growth factor receptor (EGFR)
Hirota et al., Am J Physiol Gastrointest Liver Physiol 2012 : However, inhibition of either Src tyrosine kinase signaling by PP2, Rho kinase signaling by Y27632, or phosphatidylinositol 3 (PI3) kinase signaling by LY294002 prevented 2fLI induced COX-2 expression
Cho et al., Cell Physiol Biochem 2012 (MAP Kinase Signaling System) : Among the signaling components of FceRI, Fyn, PI 3-kinase , Akt, and p38 MAPK positively mediated the COX-2 expression
Huang et al., Toxicol Appl Pharmacol 2013 (Inflammation) : We also found that LTA induced iNOS and COX-2 up-regulation were attenuated by p38, JNK, and PI3-kinase inhibitors