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PLAT — VEGFA
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
PLAT
→
VEGFA
(increases, VEGFA Activity)
Evidence: VEGF increases the expression and activation of the fibrinolytic proteases urokinase and tissue-type plasminogen activator but also induces expression of the prothrombotic components plasminogen activator inhibitor, VWF, and tissue factor
Text-mined interactions from Literome
Krishnamurthy et al., Prostaglandins Other Lipid Mediat 1999
:
In
tPA ,
VEGF did not
increase PGI2 production ; however, 10, 50, and 100 ng/mL EGF, enhanced ( p < 0.03 ) PGI2 production from 1.98 +/- 0.14 to 3.39 +/- 0.62, 3.62 +/- 0.26, and 2.93 +/- 0.20
Santra et al., J Neurochem 2008
:
Induction of gelatinases ( matrix metalloproteinase 2 and 9 ), the serine protease
tissue plasminogen activator and plasmin by DCN transfection in MCE cells
leads to extracellular proteolysis and to release of matrix bound
VEGF and activation of angiogenesis
Ohki et al., Blood 2010
(Ischemia) :
Thus,
tPA mobilizes CD11b ( + ) cells from the BM and
increases systemic and local ( cellular )
VEGF-A , which can locally promote angiogenesis during ischemic recovery
Valapala et al., J Cell Sci 2011
(Neovascularization, Pathologic) :
Treatment with the competitive peptide inhibits the generation of plasmin and suppresses the
VEGF induced activity of
tPA under hypoxic conditions
Wang et al., Ann Neurol 2013
(Brain Ischemia...) :
We also showed that rADAMTS13 inhibited
tPA mediated upregulation of
vascular endothelial growth factor ( VEGF ) in vascular endothelium after stroke