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PPARA — PRKAA2
Text-mined interactions from Literome
Lee et al., Biochem Biophys Res Commun 2006
:
Here we show that
AMPK activation by 5-aminoimidazole-4-carboxamide ribonucleoside ( AICAR )
increases mRNA expression of PPARalpha target genes and PGC-1 in cultured muscle cells and mouse skeletal muscle, and that inhibition of
PPARalpha and PGC-1 by siRNAs prevents AICAR stimulated increase in fatty acid oxidation
Suzuki et al., Mol Cell Biol 2007
(Neoplasms, Muscle Tissue) :
Our data thus suggest that the activation of and changes in the subcellular localization of
alpha2AMPK are
required for leptin induced stimulation of fatty acid oxidation and
PPARalpha gene expression in muscle cells
Kim et al., J Agric Food Chem 2009
(Carcinoma, Hepatocellular...) :
Taken together,
AMPK mediates CK induced suppression and activation of SREBP1c and
PPAR-alpha , respectively, and these effects seem to be one of antidiabetic and/or antihyperlipidemic mechanisms of CK in insulin-resistant HepG2 human hepatoma cells
Guo et al., Acta Pharmacol Sin 2010
(Insulinoma) :
To investigate whether
AMP activated protein kinase (AMPK) regulates the expression of pancreatic duodenal homeobox-1 (PDX-1), a beta-cell-specific transcription factor and whether
PPARalpha/gamma is
involved in the regulation of pancreatic beta-cell lines after acute stimulation ...
AMPK regulates the expression of PDX-1 at both the transcriptional and protein levels, and
PPARalpha may be acutely
involved in the regulation of INS-1 cells
Jiang et al., PloS one 2012
:
Treatment with t10c12 CLA increased
PPAR? phosphorylation in an
AMPK dependent manner and increased the amount of PPAR? bound to SIRT1