◀ Back to EPHB2
EPHB2 — PPP2CA
Text-mined interactions from Literome
Garcia et al., FEBS Lett 2002
:
This suggests that either PP1 or
PP2A or both are
necessary for
ERK5 activation
Yung et al., J Neurochem 2003
:
The
PP1/PP2A phosphatase inhibitors okadaic acid and caliculyn A, but not cyclosporine A,
delayed the removal of
ERK and Akt phosphorylation under OGD
Ory et al., Curr Biol 2003
(MAP Kinase Signaling System) :
Specific inhibition of
PP2A activity prevents the growth factor induced dephosphorylation event involved in the membrane recruitment of KSR1 and
blocks the activation of KSR1 associated MEK and
ERK
Kins et al., Am J Pathol 2003
:
In vitro, these tau phospho-epitopes can be phosphorylated by the kinases
ERK and JNK, and the kinases themselves are negatively
regulated by
PP2A ... In this study, we show that chronic inhibition of
PP2A activity in L199P transgenic mice
causes the activation of
ERK and JNK as demonstrated by the phosphorylation and nuclear accumulation of the ERK and JNK substrates, Elk-1 and c-Jun
Pei et al., Am J Pathol 2003
(Alzheimer Disease) :
These results suggest 1 ) that
PP-2A down-regulates ERK1/2, MEK1/2, and p70 S6 kinase activities through dephosphorylation at the serine/threonine residues of these kinases, and 2 ) that in AD brain the decrease in PP-2A activity could have
caused the activation of
ERK1/2 , MEK1/2, and p70 S6 kinase, and the abnormal hyperphosphorylation of tau both via an increase in its phosphorylation and a decrease in its dephosphorylation
Liu et al., Am J Physiol Heart Circ Physiol 2004
(MAP Kinase Signaling System) :
We also found that PP2A coimmunoprecipitated with
ERK and MAPK/ERK (MEK) in cardiac ventricular myocytes, and H ( 2 ) O ( 2 )
increased the ERK associated
PP2A activity that was blocked by inhibition of p38 MAPK
Liu et al., J Neurochem 2005
(Acute Disease...) :
The
PP-2A inhibitor, okadaic acid ( OA, 0.75 microm ), completely prevented tau from acute anoxia induced dephosphorylation and
restored the active forms of
ERK1/2 and JNK1/2 to the control level
Chetoui et al., Mol Immunol 2006
:
This study provides novel insights into the mechanisms by which beta1 integrins activate the ERK/MAP Kinase pathway in T cells, and is the first report to provide a
role for
PP2A in integrin mediated
ERK/MAP Kinase activation
Yumoto et al., Mol Cell Biochem 2006
(Disease Progression) :
Thus,
PP2A regulates the
ERK activity in a cell-specific manner, and it is speculated that distinct regulation of PP2A in the ErbB4 receptor signalling pathway may cause a difference in progression of cancer phenotypes
Martín-Encabo et al., Exp Cell Res 2007
(Cell Transformation, Neoplastic) :
Thus : ( i ) ectopic expression of C3G or C3GDeltaCat ( mutant lacking the GEF activity ) increases specific ERK associated PP2A phosphatase activities ; ( ii ) C3G and PP2A interact, as demonstrated by immunofluorescence and co-immunoprecipitation experiments ; ( iii ) association between
PP2A and MEK or ERK
increases in C3G overexpressing cells ; ( iv ) phosphorylated-inactive PP2A level decreases in C3G expressing clones and, most importantly, ( v ) okadaic acid reverts the inhibitory effect of C3G on
ERK phosphorylation
Heidbreder et al., Cardiovasc Res 2008
(MAP Kinase Signaling System...) :
Likewise,
RPC resulted in a considerable increase in phosphorylation of
ERK1/2 and JNK1/2 proteins in the small intestine, whereas it did not alter the MAPK phosphorylation state in the myocardium
Wang et al., Biochem Biophys Res Commun 2008
:
We found that
PP2A regulates alphaIIbbeta3 control of the
ERK signaling in a polymorphism specific fashion
Kim et al., Int J Neuropsychopharmacol 2008
:
Accordingly,
PP2A regulates acute dose- and time dependent changes in
MEK-ERK-p90RSK phosphorylation after haloperidol treatment
Kim et al., Proc Natl Acad Sci U S A 2008
(Fragile X Syndrome) :
ERK activation can be restored in KO by pretreatment with phosphatase blockers ; blocking of
PP2A by okadaic acid could successfully
restore normal
ERK activation in KO synaptoneurosomes
Yoon et al., Mol Cancer Res 2009
(MAP Kinase Signaling System) :
Small interfering RNA targeting of PP2A effectively attenuated sphingosine induced p38 MAPK activation through restoration of ERK activity, suggesting
PP2A mediated opposing regulation of
ERK and p38 MAPK
Cornell et al., Am J Physiol Lung Cell Mol Physiol 2009
(MAP Kinase Signaling System) :
We also found that
PP2A inhibition
resulted in prolonged activation of JNK, p38, and
ERK resulting in both increased transcriptional activation of the IL-8 promoter and posttranscriptional stabilization of IL-8 mRNA
Hu et al., BMC neuroscience 2009
(Brain Ischemia...) :
In addition, the
PP2A inhibitor, cantharidin,
led to an up-regulation of
ERK activity and was able to counteract Src inhibition during ischemia
Kar et al., J Leukoc Biol 2010
(Leishmaniasis, Visceral) :
On the other hand, MKP3 and
PP2A might
play significant roles in the inhibition of iNOS expression through deactivation of
ERK1/2
Park et al., Proc Natl Acad Sci U S A 2012
(Cell Transformation, Neoplastic) :
The activated
PP2A then
suppressed ERK signaling through dephosphorylation of ERK and induced apoptosis
Park et al., Biochim Biophys Acta 2012
(Pancreatic Neoplasms) :
Novel involvement of leukotriene B4 receptor 2 through
ERK activation by
PP2A down-regulation in leukotriene B4-induced keratin phosphorylation and reorganization of pancreatic cancer cells
Sunahori et al., J Biol Chem 2013
(Lupus Erythematosus, Systemic) :
Our results demonstrate that
PP2A regulates DNA methylation by influencing the phosphorylation of
MEK/ERK