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IGF1 — PRG4

Text-mined interactions from Literome

Harvey et al., J Biol Chem 1999 : It is likely that the local increase in IGF-I may lead to an increase in cartilage type proteoglycan synthesis and maintenance of the cartilage phenotype
van Susante et al., J Orthop Res 2000 : Recombinant human insulin-like growth factor-1 and recombinant human transforming growth factor-beta2 stimulated proteoglycan synthesis in a dose dependent and reversed dose dependent fashion, respectively
Studer et al., Am J Physiol Cell Physiol 2000 (Osteoarthritis) : SNAP, DETA NONOate, endogenously synthesized NO in Ad-iNOS transduced cells, or IL-1 activation decreased IGF-I stimulated proteoglycan synthesis in cartilage and monolayer cultures of chondrocytes
Okuda et al., Spine (Phila Pa 1976) 2001 : Mechanisms of age related decline in insulin-like growth factor-I dependent proteoglycan synthesis in rat intervertebral disc cells ... Age related fluctuations in insulin-like growth factor-I dependent proteoglycan synthesis in rat intervertebral disc cells were investigated ... Age related changes in the expression of insulin-like growth factor-I and its receptor were assessed together with insulin-like growth factor-I dependent proteoglycan synthesis by the cultured nucleus pulposus cells ... By contrast, insulin-like growth factor-I dependent proteoglycan synthesis decreased with age, and the sharpest decline of synthesis was found between 8-week and 40-week cells, although the level of insulin-like growth factor-I/insulin-like growth factor-I receptor gene expression was maintained in 40-week-old animals ... The present findings indicate that the age related decline in insulin-like growth factor-I dependent proteoglycan synthesis in nucleus pulposus is caused , at least in part, by the increase in insulin-like growth factor binding proteins at the early stages of aging, and further suggest that a loss of proteoglycan synthesis during the late stages of aging is caused by the downregulation of insulin-like growth factor-I receptor in addition to an increase in insulin-like growth factor binding proteins ... The present findings indicate that the age related decline in insulin-like growth factor-I dependent proteoglycan synthesis in nucleus pulposus is caused, at least in part, by the increase in insulin-like growth factor binding proteins at the early stages of aging, and further suggest that a loss of proteoglycan synthesis during the late stages of aging is caused by the downregulation of insulin-like growth factor-I receptor in addition to an increase in insulin-like growth factor binding proteins
Hiraoka et al., Virchows Arch 2002 (Bone Neoplasms...) : In vitro, the proteoglycan synthesis of SW1353 cells was increased by IGF-I in a dose dependent manner
Serra et al., Am J Vet Res 2002 (Dog Diseases...) : Effect of transforming growth factor-beta1, insulin-like growth factor-I , and hepatocyte growth factor on proteoglycan production and regulation in canine melanoma cell lines
Jin et al., Arch Biochem Biophys 2003 : In the absence of tissue shear, IGF-I augmented protein and proteoglycan synthesis up to twofold at IGF-I concentrations in the range of 100-300 ng/ml
Studer et al., J Orthop Res 2003 : Tissues were exposed to NO from iNOS induced by IL-1, and proteoglycan synthesis in response to IGF-1 was evaluated in the presence and absence of cGMP dependent protein kinase ( PKG ) inhibitors
Tesch et al., J Orthop Res 1992 : When these growth factors were added to articular cartilage explants complexed with their native serum binding proteins ( BPs ), both IGF-I-BP complex and IGF-II-BP complex stimulated proteoglycan synthesis to different degrees over a 3-day period
Mitropoulou et al., Biochimie 2004 (Breast Neoplasms) : IGF-I affects glycosaminoglycan/proteoglycan synthesis in breast cancer cells through tyrosine kinase dependent and -independent pathways ... The effect of IGF on proteoglycan ( PG ) synthesis by two human breast cancer epithelial cell lines, the ER-positive MCF-7 and the ER-negative BT-20, was studied alone and in combination with genistein
Martin et al., Biorheology 2004 (Osteoarthritis) : We have found that articular cartilage chondrocytes show strong evidence of senescence with increasing age, including synthesis of smaller more irregular aggrecans ; increased expression of lysosomal beta-galactosidase and telomere erosion ; and decreased proteoglycan synthesis, response to the anabolic cytokine IGF-I , proliferative capacity, and mitochondrial function
De Ceuninck et al., Arthritis Res Ther 2004 (Osteoarthritis) : It antagonized the inhibitory effect of IGFBP-3 on IGF-1 dependent proteoglycan synthesis by rabbit chondrocytes ... The addition of NBI-31772 to human OA chondrocytes resulted in the restoration or potentiation of IGF-1 dependent proteoglycan synthesis, depending on the IGF-1 concentrations
Starkman et al., Biochem J 2005 : A decrease in IGF-I stimulated proteoglycan synthesis was also observed upon inhibition of mTOR ( mammalian target of rapamycin ) and p70S6 kinase, both of which are downstream of Akt
Imai et al., Acta Endocrinol (Copenh) 1992 (Eye Diseases...) : The effects of IGF-1 and PDGF on hyaluronan and proteoglycan synthesis were studied separately and in combination ... Both IGF-1 and PDGF increased the synthesis of hyaluronan and proteoglycan in a dose dependent manner ... In contrast, IGF-1 stimulated secretion of small proteoglycan while PDGF had little effect on proteoglycan synthesis in skin fibroblasts ... In contrast, IGF-1 stimulated secretion of small proteoglycan while PDGF had little effect on proteoglycan synthesis in skin fibroblasts
Jenniskens et al., Osteoarthritis Cartilage 2006 : Examine effects of insulin-like growth factor 1 (IGF1) , transforming growth factor beta2 ( TGFbeta2 ) and fibroblast growth factor 2 (FGF2) on proteoglycan and collagen network and biomechanical properties of the newly formed cartilage matrix ... IGF1 increased collagen and proteoglycan deposition
Leach et al., Domest Anim Endocrinol 2007 : In cell culture, IGF-I stimulated proteoglycan synthesis and increased the expression of Indian hedgehog (Ihh) and type X collagen, markers of chondrocyte differentiation ... In cell culture, IGF-I stimulated proteoglycan synthesis and increased the expression of Indian hedgehog (Ihh) and type X collagen, markers of chondrocyte differentiation
Yin et al., J Biol Chem 2009 : Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways
Itagane et al., Endocrinology 1991 : The effects of IGF-I on proteoglycan synthesis, as judged by the incorporation of [ 35S ] sulfate, were stimulated by treatment with progesterone or testosterone ... When chondrocytes were treated with hydrocortisone or dexamethasone for 24 h before the addition of IGF-I, the glucocorticoids synergistically accelerated proteoglycan synthesis mediated by IGF-I
Fosang et al., Matrix 1991 : The effect of IGF-1 ( 100 ng/ml ) on matrix degradation of proteoglycan and its ability to inhibit the effects of IL-1 ( 10 ng/ml ) was also assessed
Abrahamsson et al., J Orthop Res 1991 : To identify factors with the potential of affecting those abilities, the effects of recombinant human insulin-like growth factor ( rhIGF-I ), insulin and fetal calf serum ( FCS ) on the synthesis of proteoglycan , collagen, and non-collagen protein and cell proliferation were investigated in short-term explant cultures of the deep flexor tendon of the rabbit
Miller et al., Arthritis Rheum 2010 : We have previously modified IGF-1 by adding a heparin binding domain and have shown that this fusion protein ( HB-IGF-1 ) stimulates sustained proteoglycan synthesis in cartilage
Yammani et al., Arthritis Res Ther 2012 (MAP Kinase Signaling System) : Pretreatment of chondrocytes with eNAMPT inhibited IGF-1 stimulated proteoglycan synthesis in a dose dependent manner
Tyler et al., Biochem J 1989 : Insulin-like growth factor 1 can decrease degradation and promote synthesis of proteoglycan in cartilage exposed to cytokines ... IGF 1 induced a dose dependent 2.5-fold stimulation of proteoglycan synthesis, with a half-maximal dose of 25 ng/ml ... It is concluded that IGF 1 enhances the synthesis of aggregating proteoglycan in cartilage exposed to cytokines and can directly decrease both the basal and the cytokine stimulated degradation of proteoglycan in cartilage
Nevo et al., Mech Ageing Dev 1984 : The effects of normal human serum, insulin-like growth factor and beta-D-xyloside on the synthesis of proteoglycan , as well as their differential effect on the synthesis of chondroitin sulfate and keratan sulfate side-chains, were studied in chick embryonal cartilage
Silbergeld et al., Acta Endocrinol (Copenh) 1981 : It was postulated that IGF could stimulate proteoglycan synthesis not only by elongating existing chondroitin sulphate chains but also by increased synthesis of other sugar chains e.g. keratan sulphate and oligosaccharides
Ohlsson et al., Mol Cell Endocrinol 1993 : Both GH and insulin-like growth factor-I (IGF-I) stimulated 3H-thymidine uptake in FTC 5 : 3 ( 194 +/- 28 % and 405 +/- 127 % over control, respectively ), while proteoglycan synthesis, as measured by [ 35S ] sulphate uptake, was stimulated by IGF-I only ( 101 +/- 18 % over control ). ( ABSTRACT TRUNCATED AT 250 WORDS )
Verschure et al., J Rheumatol 1994 (Arthritis...) : Stimulation of proteoglycan synthesis by triamcinolone acetonide and insulin-like growth factor 1 in normal and arthritic murine articular cartilage
Rosselot et al., J Bone Miner Res 1994 : Effect of growth hormone, insulin-like growth factor I , basic fibroblast growth factor, and transforming growth factor beta on cell proliferation and proteoglycan synthesis by avian postembryonic growth plate chondrocytes
Lazarus et al., Lymphokine Cytokine Res 1993 : IL-1 alpha inhibited IGF-1 stimulated proteoglycan ( PG ) synthesis > 95 % at 20 ng/ml ( p < 0.01 )
van der Kraan et al., Ann Rheum Dis 1993 : The in vitro effect of IGF-I and steroids on proteoglycan synthesis in murine patellar cartilage was evaluated by [ 35S ] sulphate incorporation in combination with dissociative gel chromatography using a Sephacryl S-1000 column
van Beuningen et al., Ann Rheum Dis 1993 : In the presence of insulin-like growth factor no extra effect of TGF-beta on proteoglycan synthesis was observed
Osada et al., J Orthop Res 1996 : Autocrine/paracrine mechanism of insulin-like growth factor-1 secretion, and the effect of insulin-like growth factor-1 on proteoglycan synthesis in bovine intervertebral discs ... The present study was undertaken to investigate the effect of insulin-like growth factor-1 on proteoglycan synthesis and the autocrine/paracrine mechanism involving insulin-like growth factor-1 in the bovine coccygeal intervertebral disc ... Insulin-like growth factor-1 stimulated proteoglycan synthesis in cultured cells of the nucleus pulposus of bovine intervertebral discs in a dose dependent manner, and the effect was inhibited by an anti-insulin-like growth factor-1 monoclonal antibody ... These results suggest that insulin-like growth factor-1 stimulates proteoglycan synthesis in cells of the nucleus pulposus and that these cells in culture have an insulin-like growth factor-1 autocrine/paracrine mechanism
Bonassar et al., Exp Cell Res 1997 : Pretreatment with EGF increased the responsiveness of chondrocytes to IGF-I, resulting in 90 and 60 % augmentation of IGF-I stimulated mitotic activity and proteoglycan synthesis, respectively
Morales et al., Arch Biochem Biophys 1997 : As before, 10 ng/ml TGF-beta or IGF-1 increased proteoglycan synthesis and maintained its homeostasis
Takigawa et al., Endocrinology 1997 (Bone Neoplasms...) : Both insulin-like growth factor (IGF)-I and IGF-II increased the synthesis of cartilage-type, large proteoglycan in a human chondrosarcoma derived chondrocyte cell line, HCS-2/8 ... Both anti-IGF-IR antibody and anti-IGF-II antibody inhibited proteoglycan synthesis ... Even in the presence of anti-IGF-IR antibody, IGF-II and mannose-6-phosphate stimulated proteoglycan synthesis in the cells
Sunic et al., Endocrinology 1998 : The aim of this study was to investigate the effects of IGF-I and IL-1 on IGFBP production by ovine articular chondrocytes ( OAC ) and the roles of these IGFBPs in the regulation of proteoglycan synthesis ... Furthermore, the attenuation of IGF-I stimulated proteoglycan synthesis by IL-1alpha in OAC appears to be mediated by chondrocyte IGFBPs