Gene interactions and pathways from curated databases and text-mining

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CASP12 — PSEN1

Text-mined interactions from Literome

Kovacs et al., J Neurochem 1999 (Alzheimer Disease...) : Here we explore the effects of FAD mutant forms of PS1 on caspase activation during apoptosis
Xie et al., Brain Res 2001 (Alzheimer Disease) : Antisense par-4 treatment largely suppressed the adverse effect of the mutant PS-1 on mitochondrial dysfunction and caspase activation
Chae et al., J Neurosci Res 2010 : These results suggest that caspase-2 and/or -8 is involved in presenilin/gamma-secretase activation and Abeta production in apoptosis