Gene interactions and pathways from curated databases and text-mining

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PTBP1 — TNF

Text-mined interactions from Literome

Sato et al., J Immunol 1999 : Dual stimulations of monocyte derived DCs with TNF-alpha and IL-10 selectively antagonized their respective effects on these DC properties ... Dual stimulations of TNF-alpha plus IL-10 abolished TNF-alpha induced changes of these MAPKs in DCs
Nagayama et al., J Immunol 2000 : The ligation of DCs as well as Con A blasts by IL-12 induced the production of GM-CSF, IL-1beta, IL-6, TNF-alpha , and IFN-gamma at the transcription levels
Trinité et al., J Immunol 2000 (Leukemia L5178) : Contrasting with our previous report using cultured splenic DCs, freshly isolated splenic DCs killed YAC-1 cells using a Ca ( 2+ ) -independent mechanism, but this function did not appear mediated by Fas ligand, TNF related apoptosis inducing ligand, or TNF-alpha
Menges et al., J Exp Med 2002 (Encephalomyelitis, Autoimmune, Experimental) : In conclusion, this study describes that stimulation by TNF-alpha results in incompletely matured DCs ( semi-mature DCs ) which induce peptide-specific IL-10 producing T cells in vivo and prevent EAE
Osman et al., Immunology 2002 : In this assay we analysed the migratory ability of interleukin-4 (IL-4)/granulocyte macrophage-colony stimulating factor ( GM-CSF ) -derived immature DCs as well as mature DCs , induced by tumour necrosis factor-alpha (TNF-alpha) and modified vaccinia virus Ankara ( MVA )
Schweitzer et al., Nat Biotechnol 2002 : A 51-feature RCA cytokine glass array was used to measure secretion from human dendritic cells (DCs) induced by lipopolysaccharide (LPS) or tumor necrosis factor-alpha (TNF-alpha)
Latchumanan et al., J Immunol 2002 : Further characterization of MTSA differentiated DCs showed that they were immature in nature, as stimulation of these DCs with TNF-alpha , anti-CD40, or LPS further up-regulated the surface levels of various molecules together with an increase in their T cell stimulatory capacity
Celluzzi et al., Transfusion 2003 : DCs cultured in serum-free media from adherent or CD14+ apheresis MNCs ( n = 36 ) in the presence of GM-CSF + IL4 +/- TNFalpha were frozen and stored at -80 degrees C in 6-percent HES, 5-percent DMSO, and 4-percent HSA
Xu et al., J Exp Ther Oncol 2003 (Leukemia) : Because TNF-alpha has been shown to induce the activation and maturation of dendritic cells (DCs), we investigated the effect of TNF-alpha secreted by transduced cells ( 32DTNF-alpha cells ) on the activation of DCs and their role in the production of antileukemic cytotoxic T lymphocytes ( CTLs )
Bacot et al., J Leukoc Biol 2003 (Inflammation...) : Phenotypic activation of DCs exposed to PrP ( 106-126 ) is partly a result of an autocrine TNF-alpha response and results in an increased ability of these cells to induce lymphocyte proliferation
Chomarat et al., J Immunol 2003 : TNF , but not IL-1, induce monocytes to become DCs despite the presence of fibroblasts ... TNF induced DCs contain Langerin positive cells and are able to induce allogenic T cell proliferation
Morrison et al., Exp Mol Pathol 2003 : Increasing TNFalpha enhanced the survival of culturing stem cells and resulted in a parallel increase in day 14 DCs
Iijima et al., Immunology 2003 : SB203580, a specific inhibitor of p38 MAPK, partially or markedly inhibited the phenotypic changes of DCs induced by TNF-alpha or DNCB, respectively
Um et al., Exp Dermatol 2004 : To summarize, our results suggest that TNF-alpha controls not only the inflammatory functions of DCs but also their survival
Carrasco et al., J Gen Virol 2004 : Stimulation of DCs with IFN-alpha/TNF-alpha or polyinosinic-polycytidylic acid ( pIC ) induced phenotypic maturation with increased MHC and CD80/86 expression, both with mock treated and infected DCs
Hahm et al., Virology 2004 (Measles) : Individual expression of human SLAM, interferon alpha/beta receptor, tumor necrosis factor-alpha , and lymphotoxin-alpha or beta from T cells was not required for MV-infected DCs to inhibit the proliferation of T cells
Reich et al., Exp Dermatol 2004 (Dermatitis, Atopic...) : Stimulation of day 8 DCs from AD patients with TNF-alpha and IL-1beta enhanced the expression of CD83 and CD86 and restored the production of IL-16
Nakashima et al., Cancer Chemother Pharmacol 2005 (Neoplasms) : Mature Mo-DCs ( mMo-DCs ) were induced from imMo-DCs with tumor necrosis factor-alpha and prostaglandin E ( 2 )
Nakahara et al., Clin Exp Immunol 2005 (Neoplasms) : However, TNF-alpha stimulated DCs produce low levels of IL-12
Sheng et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2005 (Leukemia) : DCs induced by GM-CSF+IL-4 and TNF-alpha had DC-classical phenotypic characteristics
Xie et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2006 (Stomach Neoplasms) : DCs in peripheral blood mononuclear cells ( PBMCs ) from gastric cancer patients were induced with rhGM-CSF, rhIL-4 and TNF-alpha
Hu et al., Infect Immun 2006 : In addition, Campylobacter infected DCs triggered activation of NF-kappaB and significantly stimulated production of interleukin-1beta (IL-1beta), IL-6, IL-8, IL-10, IL-12, gamma interferon, and tumor necrosis factor alpha (TNF-alpha) compared to uninfected DCs
Hua et al., Nan Fang Yi Ke Da Xue Xue Bao 2006 : The DCs were derived from healthy human peripheral blood monocytes in the presence of granulocyte-macrophage colony stimulating factor, interleukin (IL)-4 and tumor necrosis factor (TNF) alpha
Gao et al., Toxicol Appl Pharmacol 2007 : After LPS stimulation, IL-6, IL-10, IL-12 ( p70 ), and TNF-alpha levels significantly increased with both Pb-DCs and DCs, but Pb-DCs produced significantly less cytokines than did DCs, except for IL-10, which further supports Pb-DC preferential skewing toward type-2 immunity
Salazar et al., Ann Rheum Dis 2008 (Arthritis, Experimental...) : Tumour necrosis factor (TNF) stimulated DCs have been shown to restore tolerance in experimental autoimmune encephalomyelitis and collagen induced arthritis ( CIA )
Gu et al., Cell Mol Immunol 2008 (Neoplasms) : Differential expression patterns of PD-L1 and PD-L2 were found when DCs were triggered by CD40 ligand and TNF-alpha ... PD-L1 expression was repressed and PD-L2 expression remained unchanged in mature CD40 ligated DCs, whereas TNF-alpha stimulated DCs kept high expression of PD-L1 and significantly enhanced PD-L2 expression on DCs
Maneechotesuwan et al., J Allergy Clin Immunol 2009 (Asthma) : Using real-time RT-PCR and HPLC, the expression and activity of IDO were assessed in TNF-alpha induced mature DCs from HDM-sensitive and nonatopic patients with asthma in response to Der p 1 exposure ex vivo
Koga et al., Immunity 2009 : Overexpression of c-Fos suppressed LPS induced cytokine production, whereas cAMP mediated suppression of TNF-alpha and IL-12 was impaired in Fos ( -/- ) DCs or in RAW264.7 cells treated with c-Fos siRNA
Wong et al., J Immunol 2009 : IL-12p70 production was produced predominantly by CD8alpha ( + ) DCs and plasmacytoid DCs, and mediated by CD8 T cell derived cytokines IFN-gamma, GM-CSF, TNF-alpha , and surface CD40L
Saalbach et al., J Invest Dermatol 2010 (Inflammation) : In accordance with the elevated MMP-9 release, on co-culture with TNFalpha/IL-1beta stimulated fibroblasts, DCs migrated significantly more effectively through matrigel matrices than did TNFalpha/IL-1beta stimulated DCs
Krausgruber et al., Blood 2010 : We demonstrate that DCs but not macrophages have high levels of IRF5 protein, and that IRF5 is responsible for the late-phase expression of TNF , which is absent in macrophages ... Sustained TNF secretion is essential for robust T-cell activation by DCs
Marin-Esteban et al., J Immunother 2010 (Neoplasms) : LPS stimulation of DCs induced IL-10, IL-12p70, TNFalpha and IL-1beta secretion, and taxol pretreatment modified this response by down regulating IL-1beta secretion whereas colchicine induced a proinflammatory cytokine profile with reduced IL-10 and increased IL-12p70 and TNFalpha secretion
Lee et al., Br J Pharmacol 2010 (Asthma...) : Shikonin treated BM-DCs were poor stimulators of CD4 ( + ) T lymphocyte and induced lower levels of interleukin (IL)-4, IL-5, IL-13 and tumour necrosis factor (TNF)-a release by responding T-cells
Oliveira et al., J Biol Chem 2011 : R. sanguineus tick saliva inhibited IL-12p40 and TNF-a while potentiating IL-10 cytokine production by bone marrow derived DCs stimulated by Toll-like receptor-2, -4, and -9 agonists
Chong et al., Eur J Immunol 2011 : Importantly, these Tip-DCs were capable of further driving Th1 responses by priming naive CD4 ( + ) T cells for proliferation and IFN-? production and this was partially dependent on Tip-DC production of TNF-a and NO
Yekollu et al., Diabetes 2011 (Insulin Resistance...) : Targeting Tip-DCs and ATMs with curcusomes in ob/ob mice reduced NF-?B/RelA DNA binding activity, reduced TNF , and enhanced interleukin-4 production
Kim et al., Clin Exp Immunol 2012 (Carcinoma, Renal Cell...) : Interaction of DCs pulsed with CA9-AbOmpA fusion proteins with naive T cells stimulated secretion of IL-2, interferon ( IFN ) -? and tumour necrosis factor (TNF)-a in T cells
Moreno et al., Mem Inst Oswaldo Cruz 2012 : EIEC triggered DCs to produce interleukin (IL)-10, IL-12 and tumour necrosis factor (TNF)-a, whereas S. flexneri induced only the production of TNF-a
Kumar et al., Parasite Immunol 2012 : Here, we show that parasite GPIs efficiently activate DCs through TLR2 mediated signalling mechanism and induce the production of TNF-a and IL-12
Chentoufi et al., Viral Immunol 2012 (Herpes Simplex) : Here we show for the first time that this is associated with LAT expression, since compared to LAT? virus : ( 1 ) LAT? virus interfered with expression of MHC class I and the co-stimulatory molecules CD80 and CD86 on the surface of DCs ; ( 2 ) LAT? virus impaired DC production of the proinflammatory cytokines IL-6, IL-12, and TNF-a ; and ( 3 ) DCs infected in vitro with LAT? virus had significantly reduced the ability to stimulate HSV-specific CD8? T cells
Chen et al., Curr Drug Deliv 2012 (Carcinoma, Hepatocellular...) : The GM-CSF and IL-4 induced DCs precursor cell differentiation to DCs, the TNF-a promoted the immature DCs developed to mature DCs
Carow et al., PLoS Pathog 2013 : Instead, SOCS3 expression in infected macrophages and DCs prevented the IL-6 mediated inhibition of TNF and IL-12 secretion and contributed to a timely CD4+ cell dependent IFN-? expression in vivo
Siena et al., Exp Hematol 1995 (Neoplasms) : We show that the GM-CSF-plus-TNF-alpha dependent ex vivo generation of DCs from mobilized CD34+ cells is 2.5-fold enhanced by flk-2/flt-3 ligand or c-kit ligand ( stem cell factor ) and five-fold enhanced by a combination of these growth factors