Gene interactions and pathways from curated databases and text-mining

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IFNG — PTGS2

Text-mined interactions from Literome

Perkins et al., J Leukoc Biol 1999 : LPS and IFN-gamma induced COX-2 protein expression was not decreased in cultures treated with AG for 2 h, illustrating that AG does not inhibit the formation of COX-2 protein
Matsuura et al., J Biol Chem 1999 (Carcinoma, Squamous Cell) : Regulation of cyclooxygenase-2 by interferon gamma and transforming growth factor alpha in normal human epidermal keratinocytes and squamous carcinoma cells ... Activation of the epidermal growth factor receptor (EGFR) signaling pathway due to the enhanced transforming growth factor alpha ( TGFalpha ) expression plays an important role in the induction of COX-2 by IFN-gamma ... This is supported by the ability of TGFalpha to rapidly induce COX-2 and the inhibition of the IFN-gamma mediated COX-2 mRNA induction by an EGFR antibody and EGFR-selective kinase inhibitors
Mutoh et al., Carcinogenesis 2000 (Adenocarcinoma...) : Interferon gamma suppressed this COX-2 promoter activity, while 12-O-tetradecanoylphorbol-13-acetate and transforming growth factor alpha ( TGFalpha ) exerted enhancing effects
Mei et al., FASEB J 2000 : We found that the induction of PGHS-2 and generation of PGE2 in these cells by IFN-gamma and lipopolysaccharide (LPS) were greatly reduced by two selective NOS II inhibitors, L-NIL and SMT. To ascertain the effect of NO on PGHS-2 overexpression, we tested NO-releasing compounds, NOR-1 and SNAP, and found that they caused PGHS-2 expression and PGE2 production
Hayashi et al., Cytokine 2000 : These results indicate that IL-1beta induced delayed PGE ( 2 ) generation in these human fibroblasts mainly depends on de novo induction of COX-2 and cPLA(2), irrespective of the constitutive presence of COX-1, and that IFN-gamma and IL-4 inhibit IL-1beta induced delayed PGE ( 2 ) generation by suppressing, predominantly, COX-2 expression
Blanco et al., J Exp Med 2000 (Shock, Septic) : Interferon regulatory factor (IRF)-1 and IRF-2 regulate interferon gamma dependent cyclooxygenase 2 expression ... In this study, we demonstrate that interferon (IFN)-gamma alone or in synergy with lipopolysaccharide (LPS) or interleukin 1alpha induces Cox-2 expression in mouse peritoneal macrophages, which is paralleled by changes in Cox-2 protein levels and prostaglandin E ( 2 ) ( PGE ( 2 ) ) release
Giroux et al., J Immunol 2000 : Whereas LPS induced COX-2 mRNA and protein expression were down-regulated in DN PKC-alpha overexpressing clones, IFN-gamma induced COX-2 expression was up-regulated in DN PKC-alpha overexpressing clones with respect to normal RAW 264.7 cells ... Taken together, these results suggest a role for PKC-alpha in the modulation of LPS- and IFN-gamma induced COX-2 expression, as well as in IFN-gamma induced PGE2 secretion
Whan Han et al., Br J Pharmacol 2001 : Ergolide inhibited nuclear factor-kappaB (NF-kappaB) activation, a transcription factor necessary for iNOS and COX-2 expression in response to LPS/IFN-gamma
Yamada et al., Clin Exp Immunol 2002 (Urinary Bladder Neoplasms) : NS398, a specific COX-2 inhibitor, and indomethacin ( IM ), a COX-1 and COX-2 inhibitor, enhanced viable BCG induced cytotoxic activity and IFN-gamma and TNF-alpha production of PEC
Murakami et al., Carcinogenesis 2002 (Adenocarcinoma...) : The combined lipopolysaccharide- and interferon-gamma stimulated protein expressions of inducible nitric oxide synthase and cyclooxygenase (COX)-2 , together with the release of tumor necrosis factor-alpha, in RAW 264.7 mouse macrophages were also markedly diminished
Basu et al., Glia 2002 (Brain Injuries...) : These studies demonstrated that IL-1beta, TNFalpha, IL-6, but not IFN-gamma increase the expression of Cox-2 , whereas they all increase the expression of HCK and FAK
Raso et al., Br J Pharmacol 2002 : Leptin potentiates IFN-gamma induced expression of nitric oxide synthase and cyclo-oxygenase-2 in murine macrophage J774A.1
Zhang et al., J Endotoxin Res 2002 : Although previous studies have implicated two DNA binding proteins, interferon regulatory factor (IRF)-1 and IRF-2, in the regulation of LPS- and IFN-gamma induced COX-2 , their effects in vivo and in vitro are not well defined
Janicke et al., Res Vet Sci 2003 : Lipopolysaccharide and interferon gamma activate nuclear factor kappa B and induce cyclo-oxygenase-2 in equine vascular smooth muscle cells
Kim et al., J Immunol 2003 (Inflammation) : In both rat primary microglia and murine BV2 microglial cells, curcumin effectively suppressed the ganglioside-, LPS-, or IFN-gamma stimulated induction of cyclooxygenase-2 and inducible NO synthase, important enzymes that mediate inflammatory processes
Timoshenko et al., Int J Cancer 2004 (Mammary Neoplasms, Experimental) : Both nonselective and selective COX-2 inhibitors suppressed IFN-gamma + LPS induced NO production, which was largely restored by exogenous PGE ( 2 ) or EP ( 4 ) receptor agonist PGE ( 1 ) alcohol
Chae et al., Immunopharmacol Immunotoxicol 2004 : Salicylate treatment inhibited COX-2 expression induced by TNF-alpha/IFN-gamma and regulated the activation of ERK, IKK and IkappaB degradation and subsequent NF-kappaB activation in MC3T3E1 osteoblasts
Hanna et al., Am J Reprod Immunol 2004 (Obstetric Labor, Premature) : IFN-gamma mediated inhibition of COX-2 expression in the placenta from term and preterm labor pregnancies ... The aim of this study was to evaluate the effects of interferon (IFN)-gamma on the expression of Cyclooxygenase (COX)-2 and production of prostaglandin E ( 2 ) ( PGE ( 2 ) ) in the human placenta from term and preterm labor deliveries ... IFN-gamma significantly inhibited COX-2 expression and PGE ( 2 ) release in cultured placental explants from term and preterm labor deliveries ... Our data suggest that the human placenta is an important site for IFN-gamma mediated repression of COX-2 expression and PGE2 production, implying that functional withdrawal of IFN-gamma may be involved in the onset of term or preterm labor
Stamp et al., J Rheumatol 2004 : Paracrine upregulation of monocyte cyclooxygenase-2 by mediators produced by T lymphocytes : role of interleukin 17 and interferon-gamma
Janabi et al., J Neuroimmunol 2004 (Glioma) : Differential effects of interferon-gamma on the expression of cyclooxygenase-2 in high-grade human gliomas versus primary astrocytes ... We compared effects of interferon-gamma (IFNgamma) on cyclooxygenase-2 (COX-2) expression in malignant human glioma cell lines and cultured primary human astrocytes ... While IFNgamma inhibited interleukin-1beta (IL1beta) induced expression of COX-2 in the glioma cells, it enhanced expression in primary astrocytes ... This inhibitory effect of IFNgamma on expression of COX-2 in human glioma cells may have relevance for immunotherapies directed against high-grade gliomas
Shibata et al., J Leukoc Biol 2005 : In the presence of LPS and IFN-gamma , PGHS-2 expression and PGE2 release by IL-10 ( -/- ) and Balb/c splenic MO were enhanced compared with stimulation with LPS alone or IFN-gamma alone
Kim et al., Biochem Biophys Res Commun 2005 : Protein expression of inducible nitric oxide synthase and cyclooxygenase-2 , and production of NO by these cells were induced by LPS or IFN-gamma
Vila-del Sol et al., J Immunol 2005 : IFN-gamma induces cyclooxygenase (COX)-2 expression and PG production in mouse macrophage cells ... IFN-gamma activates COX-2 promoter-driven transcription ... In this region a NF-kappaB site has been described and mutation of this site impairs the induction of the full COX-2 promoter by IFN-gamma ... Moreover, IFN-gamma induction of the COX-2 promoter was also strongly reduced by transfection of plasmid encoding the NF-kappaB inhibitor, IkappaBalpha ... Interestingly, IFN-gamma induction of the COX-2 and PGE ( 2 ) synthesis was absent in macrophages from TNF ( -/- ) mice, and neutralizing anti-TNF Abs inhibited COX-2 promoter induction by IFN-gamma in RAW 264.7 macrophages
Dinkova-Kostova et al., Proc Natl Acad Sci U S A 2005 (Inflammation) : A series of synthetic triterpenoid ( TP ) analogues of oleanolic acid are powerful inhibitors of cellular inflammatory processes such as the induction by IFN-gamma of inducible nitric oxide synthase (iNOS) and of cyclooxygenase 2 in mouse macrophages
Sheu et al., Cell Signal 2005 (Inflammation) : LPS/IFN-gamma induced COX-2 expression in mesangial cells could be inhibited by iNOS inhibitor, aminoguanidine
Hamby et al., J Neurosci Methods 2006 : Purified monolayers appeared morphologically normal 24h after LME treatment and expressed nitric oxide synthase-2 (NOS-2) and cyclooxygenase-2 (COX-2) proteins upon stimulation with LPS plus IFNgamma , albeit to a lower level than unpurified monolayers
Han et al., Endocrinology 2006 (Graves Ophthalmopathy) : In addition, interferon gamma inhibits IL-1beta provoked PGHS-2 mRNA stability
Deng et al., Blood 2006 : LPS or LPS plus interferon-gamma (IFNgamma) increased binding of all 5 isoforms of NF-kappaB to COX-2 and iNOS promoters
Matheus et al., Eur J Pharmacol 2007 : We designed to investigate the inhibitory effect of isatin derivatives on lipopolysaccharide/interferon-gamma induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins, production of prostaglandin E ( 2 ) ( PGE ( 2 ) ), nitric oxide ( NO ), tumor necrosis factor ( TNF-alpha ), and their capacity to scavenge NO
Uto et al., Oncol Rep 2007 : IFN-gamma did not induce any activation of these factors, but 6-MITC suppressed IFN-gamma induced COX-2 expression, suggesting that the upstream region of the core element is linked for this suppression ... These results suggest that LPS, IFN-gamma and TPA regulate COX-2 expression through different mechanisms, and 6-MITC acts as a potent inhibitor of COX-2 expression induced by LPS or IFN-gamma
Hayashi et al., J Immunol 2007 (Acute Disease...) : Indeed, IFN-gamma acetylated Stat1 and reciprocally reduced NF-kappaB activation and COX-2 expression in neutrophils
Taubert et al., Vet Res Commun 2008 : Furthermore, IFNgamma-stimulation led to a strong upregulation in the transcription of VCAM-1, ICAM-1, CXCL10 and CCL2 genes and to a low to moderate increase in the E- and P-selectin, CXCL1, CXCL8, CCL5, COX-2 and iNOS gene transcripts, but failed to enhance GM-CSF gene transcription
Deng et al., Arterioscler Thromb Vasc Biol 2007 : Interferon-gamma suppresses cyclooxygenase-2 promoter activity by inhibiting C-Jun and C/EBPbeta binding ... We postulated that IFNgamma suppresses COX-2 expression at the transcriptional level ... The effect of IFNgamma on COX-2 expression was evaluated in several types of human cells stimulated with phorbol 12-myristate 13-acetate ( PMA ), interleukin (IL)-1beta, or tumor necrosis factor (TNF) alpha ... IFNgamma suppresses proinflammatory mediator induced COX-2 transcription by selective inhibition of C-Jun and C/EBPbeta DNA binding activity and p300 recruitment in human cells
Esposito et al., J Pineal Res 2008 : Moreover, Western blot analysis showed that melatonin inhibited LPS/IFN-gamma induced expression of COX-2 protein, but not that of constitutive cyclooxygenase
Boost et al., BMC cancer 2008 (Lung Neoplasms...) : In contrast to IL-8, IL-1beta induced cyclooxygenase-2 expression and release of IL-6 were not affected by IFNgamma indicating that modulation of IL-1beta action by this cytokine displays specificity
Martinet et al., Eur J Immunol 2009 : COX-2 expression and PGE ( 2 ) production by MSC were not constitutive, but were induced by IFN-gamma and TNF-alpha secreted by activated Vgamma9Vdelta2 T cells
Lee et al., Biocell 2009 : Particularly, interferon gamma (IFNgamma) induced COX-2 expression appears in inflammatory conditions such as viral infection and autoimmune diseases ... Based on the above description, we compared the effect of simvastatin on IFNgamma induced COX-2 expression in human monocytes versus murine macrophages ... In a result, we found that simvastatin suppresses IFNgamma induced COX-2 expression in human THP-1 monocytes, but rather, potentiates IFNgamma induced COX-2 expression in murine RAW264.7 macrophages ... Our findings showed that simvastatin is likely to suppress IFNgamma induced COX-2 expression by inhibiting STAT1/3 activation in human THP-1 cells, but not in murine RAW264.7 cells ... Thus, we concluded that IFNgamma induced COX-2 expression is differently regulated by simvastatin depending on species specific mechanism
Misko et al., J Neuroimmunol 1995 (Encephalomyelitis, Autoimmune, Experimental...) : Mediation of inflammation by encephalitogenic cells : interferon gamma induction of nitric oxide synthase and cyclooxygenase 2
Riese et al., J Leukoc Biol 1994 : In the presence of IFN-gamma and LPS, PGHS-2 mRNA expression reached a maximum at 8 h but PGHS-1 mRNA was not induced during the whole time period
Endo et al., J Immunol 1996 : LPS dependent cyclooxygenase-2 induction in human monocytes is down-regulated by IL-13, but not by IFN-gamma
Pang et al., Br J Pharmacol 1997 : Effect of interleukin-1 beta, tumour necrosis factor-alpha and interferon-gamma on the induction of cyclo-oxygenase-2 in cultured human airway smooth muscle cells
von Knethen et al., FASEB J 1997 : Our results point to cyclooxygenase-2 induction by lipopolysaccharide/interferon gamma/N(G)-monomethyl-L-arginine or low-dose nitric oxide pretreatment conferring macrophage protection to the apoptotic action of nitric oxide
Moos et al., J Immunol 1999 : Taxol alone or taxol plus IFN-gamma increased PGE2 formation, PGHS-2 protein expression, and PGHS-2 mRNA expression in RAW 264.7 murine macrophages