UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to IL3

IL3 — PTPN11

Pathways - manually collected, often from reviews:

NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA) → GRB2/GAB2 complex (GRB2-GAB2) (modification, collaborate)
Edmead et al., Cell Signal 2006, Welham et al., J Biol Chem 1994, Gu et al., J Biol Chem 1997, Craddock et al., J Biol Chem 1997, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2/GRB2/GAB2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA-GRB2-GAB2) (modification, collaborate)
Edmead et al., Cell Signal 2006, Welham et al., J Biol Chem 1994, Gu et al., J Biol Chem 1997, Craddock et al., J Biol Chem 1997, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL3-mediated signaling events: GRB2/GAB2 complex (GRB2-GAB2) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2/GRB2/GAB2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA-GRB2-GAB2) (modification, collaborate)
Edmead et al., Cell Signal 2006, Welham et al., J Biol Chem 1994, Gu et al., J Biol Chem 1997, Craddock et al., J Biol Chem 1997, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA) (modification, collaborate)
Welham et al., J Biol Chem 1994, Bone et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA) → SHP2 (PTPN11) (modification, collaborate) Welham et al., J Biol Chem 1994, Bone et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA) → SHP2 (PTPN11) (modification, collaborate) Welham et al., J Biol Chem 1994, Bone et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
Reactome Reaction: IL3 → PTPN11 (reaction) Bone et al., J Biol Chem 1997
Reactome Reaction: IL3 → PTPN11 (indirect_complex) Bone et al., J Biol Chem 1997

Text-mined interactions from Literome

Wheadon et al., Biochem J 2003 : To investigate the role of SHP-2 in IL-3 signalling in greater detail, we have inducibly expressed WT ( wild-type ) or two potentially substrate trapping mutant forms of SHP-2, generated by mutation of Asp-425 to Ala ( D425A ) or Cyst-459 to Ser ( C459S ), in IL-3 dependent BaF/3 cells
Welham et al., J Biol Chem 1994 : Interleukin (IL)-3 and granulocyte/macrophage colony stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase
Chin et al., Biochem Biophys Res Commun 1997 : Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2 , and Cbl in hematopoietic cells ... The present study demonstrates that erythropoietin (Epo) and IL-3 induce tyrosine phosphorylation of the SH2/SH3 containing adapter protein CrkL and its transient association with tyrosine phosphorylated SHP-2 , Shc, and Cbl in a murine IL-3 dependent cell line, 32D, expressing the Epo receptor (EpoR)