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NOS3 — RHOA

Text-mined interactions from Literome

Eto et al., Circ Res 2001 : Inhibition of Rho A by C3 exoenzyme ( 20 microgram/mL ) and ROCK by Y-27632 ( 10 micromol/L ) prevented the downregulation of eNOS expression by thrombin
Ming et al., Mol Cell Biol 2002 : Using adenovirus mediated gene transfer in human umbilical vein endothelial cells ( HUVECs ), we show here that both active RhoA and ROCK not only downregulate eNOS gene expression as reported previously but also inhibit eNOS phosphorylation at Ser-1177 and cellular NO production with concomitant suppression of PKB activation ... Moreover, coexpression of a constitutive active form of PKB restores the phosphorylation but not gene expression of eNOS in the presence of active RhoA
Barandier et al., Biochem Biophys Res Commun 2003 : We showed that expression of constitutively active RhoA ( Rho63 ) or ROCK ( CAT ) suppressed eNOS gene expression
Rattan et al., Free Radic Biol Med 2003 : Rho A negatively regulates cytokine mediated inducible nitric oxide synthase expression in brain derived transformed cell lines : negative regulation of IKKalpha
Viswambharan et al., Circ Res 2004 : In conclusion, rHDL inhibits thrombin induced human endothelial TF expression through inhibition of RhoA and activation of PI3K but not Akt/eNOS
Bivalacqua et al., Proc Natl Acad Sci U S A 2004 (Body Weight...) : RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis : a mechanism for diabetes associated erectile dysfunction ... RhoA/Rho-kinase may suppress endothelial nitric oxide synthase (eNOS) ... Here, we tested the hypothesis that RhoA/Rho-kinase contributes to diabetes related erectile dysfunction and down-regulation of eNOS in the streptozotocin (STZ)-diabetic rat penis
Liao et al., J Investig Med 2004 (Cardiomegaly...) : Furthermore, inhibition of RhoA by statins leads to the activation of protein kinase B/Akt and up-regulation of endothelial nitric oxide synthase in the endothelium and the heart
Mital et al., Semin Vasc Med 2004 (Cardiomegaly) : Furthermore, inhibition of RhoA by statins leads to the activation of protein kinase B/Akt and upregulation of Type 3 nitric oxide synthase in the endothelium and the heart
Jin et al., Neurosci Lett 2006 : Hypoxia induced upregulation of endothelial small G protein RhoA and Rho-kinase/ROCK2 inhibits eNOS expression ... Using the human endothelial cell line HUVEC, the present study investigated the role of RhoA and Rho-kinase in endothelial eNOS protein expression under hypoxic conditions as an in vitro model of ischemia ... The hypoxia induced decrease in eNOS expression was significantly enhanced by expression of the constitutively active form of RhoA and significantly inhibited by suppression of RhoA expression by small interfering RNA ... Since expression and activation of RhoA and Rho-kinase inhibit eNOS expression in endothelial cells, attempts to down-regulate RhoA and Rho-kinase by multiple drugs, such as statins or Rho-kinase inhibitors, might provide endothelial and cardiovascular benefits through upregulation of eNOS
Trebicka et al., Hepatology 2007 (Liver Cirrhosis) : Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase
Soliman et al., Cardiovasc Res 2008 (Diabetes Mellitus, Experimental...) : Role of inducible nitric oxide synthase in induction of RhoA expression in hearts from diabetic rats
Sawada et al., Expert Rev Neurother 2009 (Stroke) : The upregulation of eNOS by statins is mediated by inhibition of small GTP binding protein RhoA