Gene interactions and pathways from curated databases and text-mining

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INS — RPS6

Text-mined interactions from Literome

Anand et al., Am J Physiol Endocrinol Metab 2002 : Initial studies demonstrated markedly decreased insulin mediated activation of ribosomal protein S6 kinase 1 ( S6K1 ) in the fetus
Suryawan et al., J Nutr 2004 : In this study, we examined the individual roles of insulin and amino acids in the activation of insulin signaling components leading to translation initiation, specifically, the insulin receptor (IR), insulin receptor substrate 1 (IRS-1), phosphatidylinositol 3-kinase ( PI 3-kinase ), protein kinase B (PKB) and ribosomal protein S6
Proud et al., Biochem Soc Trans 2006 : Insulin also stimulates synthesis of ribosomal proteins by promoting recruitment of their mRNAs into polyribosomes
Galbaugh et al., BMC cell biology 2006 : The activation of p70S6K by insulin or EGF resulted in the phosphorylation of ribosomal protein S6 (RPS6) , elongation initiation factor 4E ( elF4E ) and 4E binding protein1 (4E-BP1) ... But lower levels of PI-3-K and mTOR inhibitors were required to block insulin induced phosphorylation of RPS6 than EGF induced phosphorylation, and insulin induced phosphorylation of elF4E and 4E-BP1 was not completely mTOR dependent suggesting some diversity of signaling for EGF and insulin
Miranda et al., Pflugers Arch 2008 : Insulin , on the other hand, stimulated protein synthesis ( by 30 % ) and increased p70 ribosomal protein S6 kinase (p70S6K) Thr389, 40S ribosomal protein S6 ( rpS6 ) Ser235/236, rpS6 Ser240/244 and eukaryotic initiation factor-4E binding protein-1 (4E-BP1) Thr37/46 phosphorylation over basal values
Deshmukh et al., Mol Endocrinol 2008 : Insulin stimulation increased phosphorylation of S6K1 ( Thr389 ), ribosomal protein S6 ( Ser235/236 ), and 4E-BP1 ( Thr37/46 ) ( P < 0.01 ) in WT, AMPK alpha2 KO, and AMPK gamma3 KO mice
Price et al., Proc Natl Acad Sci U S A 1990 : The dominant insulin stimulated ribosomal protein S6 kinase activity was purified to near homogeneity from insulin treated 32P labeled rat H4 hepatoma cells and found to copurify with a 70-kDa 32P labeled polypeptide
Palaniappan et al., Mol Cell Endocrinol 2013 : Inhibition of ERK1/2 signaling caused partial reduction of insulin induced phosphorylation of RPS6KB1 and RPS6 whereas inhibition of PI3-kinase signaling completely blocked the insulin response
Villa-Hernández et al., Biochimie 2013 : Insulin increased this synthesis ( 75 % ) at 24 h of imbibition ; however, not all ribosomal proteins were similarly regulated
Abraham et al., Biochem Biophys Res Commun 1989 (Carcinoma, Hepatocellular...) : The effect of insulin on the phosphorylation of ribosomal protein S6 was studied in a human liver cell line ( HepG-2 ), using [ 32P ] inorganic phosphate
Nemenoff et al., Arch Biochem Biophys 1986 (Liver Neoplasms, Experimental) : Insulin stimulates the phosphorylation of the 40 S ribosomal subunit protein, S6, in intact 32P labeled H4IIE-C3 cells, a rat hepatoma line
Spach et al., J Biol Chem 1986 : In contrast to these differences, both insulin and PMA stimulated the phosphorylation of ribosomal protein S6 and activated a ribosomal protein S6 kinase in cell-free extracts from cells exposed to these agents ... Under these conditions, insulin , but not PMA, stimulated phosphorylation of the ribosomal protein S6 in intact cells and activated the S6 kinase in cell-free extracts derived from insulin treated intact cells
Morgan et al., Proc Natl Acad Sci U S A 1987 : Injection of this inhibitory antibody resulted in a decreased ability of insulin to stimulate the uptake of 2-deoxyglucose in Chinese hamster ovary cells and freshly isolated rat adipocytes, ribosomal protein S6 phosphorylation in CHO cells, and glycogen synthesis in the human hepatoma cell line HepG2
Hansson et al., Eur J Biochem 1985 : A similar time dependence was also observed for the insulin induced phosphorylation of ribosomal protein S6
Holland et al., FEBS Lett 1983 : These results cast doubt on previous claims that growth factors stimulate phosphorylation of ribosomal protein S6 by activating an amiloride-sensitive Na+/H+ exchange system, and that insulin inhibits a protein phosphatase that is activated by amiloride
Kulkarni et al., Biochim Biophys Acta 1983 (Melanoma...) : Insulin mediated phosphorylation of ribosomal protein S6 in mouse melanoma cells and melanoma x fibroblast hybrid cells in relation to cell proliferation ... The possible role of insulin mediated phosphorylation of ribosomal protein S6 in the control of cell proliferation was examined in insulin-unresponsive mouse melanoma calls ( PG19 ) and insulin-responsive melanoma x fibroblast clone 100A ... In the hybrid cells, under conditions of growth arrest in medium with low serum, ribosomal protein S6 was rapidly phosphorylated in response to insulin or serum
Perisic et al., J Biol Chem 1983 : Protease activated kinase II as the potential mediator of insulin stimulated phosphorylation of ribosomal protein S6
Rosen et al., J Biol Chem 1981 : Insulin stimulates the phosphorylation of ribosomal protein S6 in a cell-free system derived from 3T3-L1 adipocytes
Seger et al., J Biol Chem 1995 : Under these conditions, AG-18 inhibited insulin stimulated phosphorylation of the ribosomal protein S6 , while no inhibition of insulin induced activation of mitogen activated protein kinase ( MAPK ) kinase or MAPK was detected
Lin et al., J Biol Chem 1995 : Rapamycin abolished the effects of insulin on increasing phosphorylation of ribosomal protein S6 and on activating p70S6K
von Manteuffel et al., Mol Cell Biol 1997 : Employing specific inhibitors and docking-site mutants of growth factor receptors, recent studies have indicated that the insulin induced increase in 40S ribosomal protein S6 and initiation factor 4E binding protein 1 (4E-BP1) phosphorylation is mediated by the mTOR/FRAP-p70s6k signal transduction pathway