Gene interactions and pathways from curated databases and text-mining

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MAPK3 — RPS6KA2

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: RPS6KA2 → MAPK3 (directlyIncreases, RPS6KA2 Activity) Pullen et al., Science 1998*
    Evidence: Etienne-Manneville and Hall (2003) used primary rat astrocytes in a cell migration assay to demonstrate that PAR6-PKC-zeta interacts directly with and regulates glycogen synthase kinase-3-beta (GSK3-beta; 605004) to promote polarization of the centrosome and to control the direction of cell protrusion. CDC42-dependent phosphorylation of GSK3-beta occurs specifically at the leading edge of migrating cells, and induces the interaction of APC (175100) protein with the plus ends of microtubules. Erk...
  • KEGG Oocyte meiosis: MAPK1/MAPK3 → RPS6KA1/RPS6KA2/RPS6KA3/RPS6KA6 (protein-protein, activation)
  • KEGG Long-term potentiation: MAPK1/MAPK3 → RPS6KA1/RPS6KA2/RPS6KA3/RPS6KA6 (protein-protein, activation)
  • KEGG Neurotrophin signaling pathway: MAPK1/MAPK3 → RPS6KA1/RPS6KA2/RPS6KA3/RPS6KA6 (protein-protein, activation)
  • KEGG Progesterone-mediated oocyte maturation: MAPK1/MAPK3 → RPS6KA1/RPS6KA2/RPS6KA3/RPS6KA6 (protein-protein, activation)
  • KEGG MAPK signaling pathway: MAPK1/MAPK3 → RPS6KA1/RPS6KA2/RPS6KA3/RPS6KA6 (protein-protein, phosphorylation)
  • Reactome Reaction: RPS6KA2 → MAPK3 (reaction) Ranganathan et al., Arch Biochem Biophys 2006*
  • WikiPathways Insulin Signaling: MINK1/MAP4K4/MAP3K2/MAPK12/MAP3K5/MAPK10/MAP3K3/MAP4K1/MAPK3/MAP2K7/MAPK13/MAP3K1/MAP4K3/MAP2K6/MAP3K8/MAP3K12/MAP2K4/MAPK7/MAPK14/MAP3K11/MAP3K7/MAPK11/MAPK9/MAPK6/MAP3K13/MAP2K3/MAPK4/MAP4K2/MAP2K5/MAP3K10/MAPK1/MAP2K1/MAP3K6/MAP3K4/MAP3K9/MAP4K5/MAP2K2/MAPK8/MAP3K14 → RPS6KA4/RPS6KA3/RPS6KA6/RPS6KA5/RPS6KA1/RPS6KA2 (activation)
  • WikiPathways Angiopoietin Like Protein 8 Regulatory Pathway: MAP2K1/MAP3K7/MAPK14/MAPK1/MAP2K2/MAP3K2/MAP3K6/MAPK8/MAP4K1/MAP3K11/MAP4K3/MAPK10/MAP2K7/MAP3K4/MAP3K1/MAP3K12/MAPK4/MAPK11/MAP4K5/MAPK6/MAP4K4/MAPK3/MAP3K14/MAPK12/MAP2K5/MAP2K4/MAPK13/MAP3K5/MAPK9/MAPK7/MAP3K3/MAP3K9/MAP3K8/MAP2K6/MAP3K13/MAP4K2/MAP2K3/MAP3K10/MINK1 → RPS6KA5/RPS6KA6/RPS6KA4/RPS6KA1/RPS6KA2/RPS6KA3 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *