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AKT1 — RUNX2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: Complex of AKT1-RUNX2-DVL2-RUNX2-DVL2-AKT1-DVL2-RUNX2-AKT1 (in vivo) Wong et al., J Biol Chem 2004*

Text-mined interactions from Literome

Fujita et al., J Cell Biol 2004 : Runx2 up-regulated PI3K subunits ( p85 and p110beta ) and Akt , and their expression patterns were similar to that of Runx2 in growth plates
Qiao et al., J Biol Chem 2004 : Surprisingly, these IGF-1 mediated effects on RUNX2 were not regulated by Akt phosphorylation, a common downstream target of PI3K, as determined by pharmacological or genetic inhibition
Komori et al., Clinical calcium 2006 : Phosphoinositide 3-kinase (PI3K)-Akt signaling enhances DNA binding of Runx2 and Runx2 dependent transcription, and Runx2 upregulates PI3K subunits ( p85 and p110 beta ) and Akt
Byon et al., J Biol Chem 2008 (Atherosclerosis...) : Inhibition of H2O2 activated AKT signaling blocked VSMC calcification and Runx2 induction concurrently ... Taken together, our data demonstrate a critical role for AKT mediated induction of Runx2 in oxidative stress induced VSMC calcification
Liu et al., Biochem Biophys Res Commun 2013 : Furthermore, in the presence of exogenous BMP-2, PI3K and Akt inhibitors blocked Runx2 and osteocalcin expression, although BMP-2 did not activate Akt