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EGFR — SCAMP3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: SCAMP3 → EGFR (directlyIncreases, SCAMP3 Activity) Wu et al., Mol Biol Cell 1998*
  Evidence: EGF also induces SCAMP-EGFR association, as detected by coimmunoprecipitation, and phosphorylation of SCAMP3 is stimulated by the EGFR in vitro.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: SCAMP3 — EGFR (in vitro) Brill et al., Anal Chem 2004, Wu et al., Mol Biol Cell 1998*
• IRef Hprd Interaction: SCAMP3 — EGFR (in vivo) Brill et al., Anal Chem 2004, Wu et al., Mol Biol Cell 1998*
• IRef Mppi Interaction: EGFR — SCAMP3 (coimmunoprecipitation) Wu et al., Mol Biol Cell 1998*

Text-mined interactions from Literome

Aoh et al., Mol Biol Cell 2009 : SCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling ... We show that secretory carrier membrane protein , SCAMP3, localizes in part to early endosomes and negatively regulates EGFR degradation through processes that involve its ubiquitylation and interactions with ESCRTs
Wu et al., Mol Biol Cell 1998 : EGF also induces SCAMP-EGFR association, as detected by coimmunoprecipitation, and phosphorylation of SCAMP3 is stimulated by the EGFR in vitro