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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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MTOR — SGK1

Text-mined interactions from Literome

Mansley et al., Br J Pharmacol 2010 : TORC2 , but not TORC1, is also involved in glucocorticoid induced SGK1 activation but its role is permissive
Cheng et al., Circ Res 2010 (Carotid Artery Injuries...) : SGK-1 activation in response to stretch is blocked by insulin-like growth factor (IGF)-1 receptor inhibitor and mammalian target of rapamycin complex ( mTORC)2 inhibitor ( Ku-0063794 ) but not mTORC1 inhibitor ( rapamycin )
Lu et al., J Am Soc Nephrol 2010 : Inhibition of mTOR blocked both SGK1 phosphorylation and ENaC mediated Na+ transport, whereas specific inhibition of mTORC1 had no effect
Jones et al., PLoS Biol 2009 : These findings identify new physiological roles for TORC2 , mediated by SGK , in regulation of C. elegans lipid accumulation and growth, and they challenge the notion that AKT is the primary effector of TORC2 function
García-Martínez et al., Biochem J 2008 : mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid induced protein kinase 1 ( SGK1 )
Hong et al., Mol Cell 2008 (Melanoma) : mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation ... Cellular mTOR activation, by refeeding of amino acid deprived cells or by TSC2 shRNA, activated SGK1 and p27 phosphorylation at T157, and both were inhibited by short-term rapamycin treatment and by SGK1 shRNA ... mTOR overexpression activated both Akt and SGK1 , causing TGF-beta resistance through impaired nuclear import and cytoplasmic accumulation of p27
Hall et al., Breast Cancer Res Treat 2012 (Breast Neoplasms) : Previous studies have alternatively suggested that either mTORC1 or mTORC2 is exclusively required for SGK1 's Ser422 phosphorylation and activation in breast cancer cells ... Previous studies have alternatively suggested that either mTORC1 or mTORC2 is exclusively required for SGK1 's Ser422 phosphorylation and activation in breast cancer cells
Pearce et al., Biochem J 2011 : Both complexes phosphorylate the hydrophobic motifs of AGC kinase family members : mTORC1 phosphorylates S6K ( S6 kinase ), whereas mTORC2 regulates phosphorylation of Akt, PKCa ( protein kinase Ca ) and SGK1 ( serum- and glucocorticoid induced protein kinase 1 ) ... Taken together, these results suggest that Protor-1 may play a role in enabling mTORC2 to efficiently activate SGK1 , at least in the kidney
Dibble et al., Mol Cell Biol 2009 : However, Rictor-T1135 phosphorylation does not appear to regulate mTORC2 mediated effects on SGK1 or PKC alpha