Gene interactions and pathways from curated databases and text-mining

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CD79B — SHC1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Harmer et al., J Biol Chem 1999 : Here, we report that cross linking of the BCR induces association between Grb2 and SHIP as well as association between Shc and SHIP
Ingham et al., J Immunol 1999 : Tyrosine phosphorylation of Shc in response to B cell Ag receptor (BCR) engagement creates binding sites for the Src homology 2 (SH2) domain of Grb2 ... BCR induced tyrosine phosphorylation of Shc could be restored in the these cells by expressing wild-type SHIP but not by expressing a mutant form of SHIP that can not bind to Shc
Harrison-Findik et al., Oncogene 1995 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : P210 BCR/abl tyrosine kinase induces tyrosine phosphorylation of Shc , and activation of p21ras and PI 3-Kinase
Smit et al., Oncogene 1996 (Burkitt Lymphoma) : B-cell antigen receptor (BCR) stimulation induces tyrosine phosphorylation of the Shc adaptor protein and its association with Grb2 ... We reveal here an additional complexity of the BCR induced Shc/Grb2 complex : it contains tyrosine phosphorylated proteins of 130, 110 and 75 kDa
Harmer et al., Mol Cell Biol 1997 : Cross linking of the B-cell antigen receptor (BCR) induces tyrosine phosphorylation of Shc , which is believed to lead to the activation of Ras