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CD79B — SHC1
Pathways - manually collected, often from reviews:
-
BioCarta bcr signaling pathway:
B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
-
Reactome Reaction:
CD79B
→
SHC1
(indirect_complex)
Brooks et al., J Immunol 2000, Marshall et al., J Exp Med 2000, Fujimoto et al., Immunity 2000, Baba et al., Proc Natl Acad Sci U S A 2001, Rodriguez et al., J Biol Chem 2001, Chiu et al., EMBO J 2002, Xu et al., J Immunol 2002, Coggeshall et al., Proc Natl Acad Sci U S A 1992, Sekiya et al., J Biol Chem 2004, Brooks et al., J Immunol 2004, Roifman et al., Biochem Biophys Res Commun 1992, Kim et al., Mol Cell Biol 2004, Carter et al., Proc Natl Acad Sci U S A 1991, Weng et al., J Biol Chem 1994, Roifman et al., Biochem Biophys Res Commun 1993, Chalupny et al., EMBO J 1993, Uckun et al., J Biol Chem 1993, de Weers et al., J Biol Chem 1994, Saxton et al., J Immunol 1994, Smit et al., J Biol Chem 1996, Kuwahara et al., Int Immunol 1996, Harmer et al., Mol Cell Biol 1997, Fu et al., J Biol Chem 1997, Bae et al., J Biol Chem 1998, Fu et al., Immunity 1998
Text-mined interactions from Literome
Harmer et al., J Biol Chem 1999
:
Here, we report that cross linking of the
BCR induces association between Grb2 and SHIP as well as association between
Shc and SHIP
Ingham et al., J Immunol 1999
:
Tyrosine phosphorylation of
Shc in
response to
B cell Ag receptor (BCR) engagement creates binding sites for the Src homology 2 (SH2) domain of Grb2 ...
BCR induced tyrosine phosphorylation of
Shc could be restored in the these cells by expressing wild-type SHIP but not by expressing a mutant form of SHIP that can not bind to Shc
Harrison-Findik et al., Oncogene 1995
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
P210
BCR/abl tyrosine kinase
induces tyrosine phosphorylation of
Shc , and activation of p21ras and PI 3-Kinase
Smit et al., Oncogene 1996
(Burkitt Lymphoma) :
B-cell antigen receptor (BCR) stimulation
induces tyrosine phosphorylation of the
Shc adaptor protein and its association with Grb2 ... We reveal here an additional complexity of the
BCR induced
Shc/Grb2 complex : it contains tyrosine phosphorylated proteins of 130, 110 and 75 kDa
Harmer et al., Mol Cell Biol 1997
:
Cross linking of the
B-cell antigen receptor (BCR) induces tyrosine phosphorylation of
Shc , which is believed to lead to the activation of Ras