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SIN3A — TP53
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
TP53
—
SIN3A
Steffan et al., Proc Natl Acad Sci U S A 2000*
-
IRef Bind_translation Interaction:
TP53
—
SIN3A
(affinity chromatography technology)
Steffan et al., Proc Natl Acad Sci U S A 2000*
-
IRef Biogrid Interaction:
SIN3A
—
TP53
(physical association, affinity chromatography technology)
Zilfou et al., Mol Cell Biol 2001*
-
IRef Biogrid Interaction:
SIN3A
—
TP53
(physical association, affinity chromatography technology)
Murphy et al., Genes Dev 1999*
-
IRef Biogrid Interaction:
SIN3A
—
TP53
(direct interaction, pull down)
Murphy et al., Genes Dev 1999*
-
IRef Hprd Interaction:
TP53
—
SIN3A
(in vivo)
Steffan et al., Proc Natl Acad Sci U S A 2000*, Zilfou et al., Mol Cell Biol 2001*
-
IRef Hprd Interaction:
TP53
—
SIN3A
(in vitro)
Steffan et al., Proc Natl Acad Sci U S A 2000*, Zilfou et al., Mol Cell Biol 2001*
-
IRef Intact Interaction:
TP53
—
SIN3A
(physical association, pull down)
Steffan et al., Proc Natl Acad Sci U S A 2000*
-
IRef Intact Interaction:
TP53
—
SIN3A
(physical association, anti bait coimmunoprecipitation)
Zilfou et al., Mol Cell Biol 2001*
-
IRef Ophid Interaction:
TP53
—
SIN3A
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Koumenis et al., Mol Cell Biol 2001
(Cell Transformation, Neoplastic) :
At the molecular level, DNA damage
induces the interaction of
p53 with the transcriptional activator p300 as well as with the transcriptional corepressor
mSin3A ... In contrast, hypoxia primarily
induces an interaction of
p53 with
mSin3A , but not with p300
Xu et al., J Biol Chem 2007
:
The activity of
p53 is differentially
regulated by Brm- and Brg1 containing
SWI/SNF chromatin remodeling complexes
Zhang et al., Cancer Lett 2008
(Carcinoma, Hepatocellular...) :
Researches have shown that
ING2 can
activate p53 and p53 mediated apoptotic pathway involved in the hepatocarcinogenesis
Madapura et al., Cell cycle (Georgetown, Tex.) 2012
:
Modifying
p53 levels using Nutlin-3, which specifically dissociates the MDM2-p53 interaction, was
sufficient to upregulate
SAP expression, indicating that SAP is a target of p53 in T cells