◀ Back to FOXO3
FOXO3 — SIRT1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database FoxO family signaling:
FOXO3A (FOXO3)
→
SIRT1 (SIRT1)
(modification, collaborate)
Brunet et al., Science 2004
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FoxO family signaling:
FOXO3A (FOXO3)
→
FOXO3A/SIRT1 complex (FOXO3-SIRT1)
(modification, collaborate)
Brunet et al., Science 2004
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FoxO family signaling:
SIRT1 (SIRT1)
→
FOXO3A/SIRT1 complex (FOXO3-SIRT1)
(modification, collaborate)
Brunet et al., Science 2004
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FoxO family signaling:
FOXO3A (FOXO3)
→
FOXO3A/SIRT1 complex (FOXO3-SIRT1)
(transcription, activates)
Dijkers et al., Curr Biol 2000*, Brunet et al., Science 2004, Lehtinen et al., Cell 2006
Evidence: mutant phenotype, reporter gene
-
NCI Pathway Database FoxO family signaling:
FOXO3A/SIRT1 complex (FOXO3-SIRT1)
→
BIM (BCL2L11)
(transcription, inhibits)
Dijkers et al., Curr Biol 2000*, Brunet et al., Science 2004, Lehtinen et al., Cell 2006
Evidence: mutant phenotype, reporter gene
-
NCI Pathway Database Signaling events mediated by HDAC Class III:
FOXO3A (FOXO3)
→
SIRT1 (SIRT1)
(modification, collaborate)
Motta et al., Cell 2004*
Evidence: assay, reporter gene, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class III:
FOXO3A (FOXO3)
→
SIRT1/FOXO3a complex (FOXO3-SIRT1)
(modification, collaborate)
Motta et al., Cell 2004*
Evidence: assay, reporter gene, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class III:
SIRT1 (SIRT1)
→
SIRT1/FOXO3a complex (FOXO3-SIRT1)
(modification, collaborate)
Motta et al., Cell 2004*
Evidence: assay, reporter gene, physical interaction
-
NCI Pathway Database FoxO family signaling:
FOXO3A/SIRT1 complex (FOXO3-SIRT1)
→
p27Kip1 (CDKN1B)
(transcription, activates)
Brunet et al., Science 2004
Evidence: mutant phenotype
-
NCI Pathway Database FoxO family signaling:
FOXO3A (FOXO3)
→
FOXO3A/SIRT1 complex (FOXO3-SIRT1)
(transcription, activates)
Brunet et al., Cell 1999, Brunet et al., Science 2004
Evidence: mutant phenotype, reporter gene
-
NCI Pathway Database FoxO family signaling:
FOXO3A/SIRT1 complex (FOXO3-SIRT1)
→
FASLG (FASLG)
(transcription, inhibits)
Brunet et al., Cell 1999, Brunet et al., Science 2004
Evidence: mutant phenotype, reporter gene
-
WikiPathways NAD metabolism, sirtuins and aging:
SIRT1
→
FOXO1/FOXO3/TFAM/TFAM/PPARG
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
SIRT1
—
FOXO3
Brunet et al., Science 2004
-
IRef Bind_translation Interaction:
SIRT1
—
FOXO3
(coimmunoprecipitation)
Brunet et al., Science 2004
-
IRef Bind_translation Interaction:
SIRT1
—
FOXO3
(experimental interaction detection)
Brunet et al., Science 2004
-
IRef Biogrid Interaction:
FOXO3
—
SIRT1
(physical association, affinity chromatography technology)
An et al., Mol Cell Biol 2010*
-
IRef Biogrid Interaction:
FOXO3
—
SIRT1
(physical association, affinity chromatography technology)
Tseng et al., J Bone Miner Res 2011*
-
IRef Biogrid Interaction:
FOXO3
—
SIRT1
(physical association, affinity chromatography technology)
Brunet et al., Science 2004
-
IRef Biogrid Interaction:
FOXO3
—
SIRT1
(direct interaction, enzymatic study)
Brunet et al., Science 2004
-
IRef Biogrid Interaction:
FOXO3
—
SIRT1
(physical association, affinity chromatography technology)
van der Horst et al., J Biol Chem 2004*
-
MIPS CORUM FOXO3-SIRT1 complex, oxidative stress stimulated:
FOXO3-SIRT1 complex, oxidative stress stimulated complex (FOXO3-SIRT1)
Brunet et al., Science 2004
-
IRef Corum Interaction:
SIRT1
—
FOXO3
(association, anti bait coimmunoprecipitation)
Brunet et al., Science 2004
-
IRef Corum Interaction:
SIRT1
—
FOXO3
(association, anti tag coimmunoprecipitation)
Brunet et al., Science 2004
-
IRef Hprd Interaction:
SIRT1
—
FOXO3
(in vitro)
Brunet et al., Science 2004
-
IRef Hprd Interaction:
SIRT1
—
FOXO3
(two hybrid)
Brunet et al., Science 2004
-
IRef Hprd Interaction:
SIRT1
—
FOXO3
(in vivo)
Brunet et al., Science 2004
-
IRef Intact Interaction:
SIRT1
—
FOXO3
(physical association, anti bait coimmunoprecipitation)
van der Horst et al., J Biol Chem 2004*
-
IRef Intact Interaction:
SIRT1
—
FOXO3
(physical association, anti tag coimmunoprecipitation)
Brunet et al., Science 2004
-
IRef Intact Interaction:
SIRT1
—
FOXO3
(direct interaction, deacetylase assay)
Brunet et al., Science 2004
-
IRef Intact Interaction:
SIRT1
—
FOXO3
(physical association, anti bait coimmunoprecipitation)
Brunet et al., Science 2004
-
IRef Ophid Interaction:
SIRT1
—
FOXO3
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Nemoto et al., Science 2004
(Starvation) :
Stimulation of
SIRT1 transcription by
Foxo3a was mediated through two p53 binding sites present in the SIRT1 promoter, and a nutrient-sensitive physical interaction was observed between Foxo3a and p53
Oh et al., Mol Pharmacol 2010
:
Overexpression of
SIRT1 enhanced both
FoxO reporter activity and nuclear levels of FoxO1
Xiong et al., J Biol Chem 2011
:
Consistently,
FoxO1 overexpression
increases SIRT1 expression, and FoxO1 depletion by siRNA reduces SIRT1 expression at both the messenger RNA and protein levels in vascular smooth muscle cells and HEK293 cells
Rizki et al., PLoS Genet 2011
:
The conserved DAF-16/FOXO transcription factors and SIR-2.1/SIRT1 deacetylases are critical for diverse biological processes, particularly longevity and stress response ; and complex
regulation of
DAF-16/FOXO by
SIR-2.1/SIRT1 is central to appropriate biological outcomes
Parker et al., J Neurosci 2012
:
In Caenorhabditis elegans,
sir-2.1/SIRT1 overexpression protects neurons from the early phases of expanded polyglutamine ( polyQ ) toxicity, and this protection
requires the longevity promoting factor
daf-16/FOXO
Kok et al., Arthritis Rheum 2013
(Arthritis, Experimental...) :
To examine the
role of sirtuin-1
(SIRT-1)/FoxO3a in the expression of
cysteine-rich protein 61 (CYR-61) in rheumatoid arthritis synovial fibroblasts ( RASFs ) and the influence of simvastatin on this pathway, and to determine the relationship between disease progression and FoxO3a/CYR-61 signaling in synovial fibroblasts in vivo using a rat model of collagen induced arthritis ( CIA )