◀ Back to SLC22A3

SIX1 — SLC22A3

Text-mined interactions from Literome

Micalizzi et al., J Clin Invest 2009 (Breast Neoplasms...) : Here we show that overexpression of the homeoprotein Six1 , normally a developmentally restricted transcriptional regulator, increases TGF-beta signaling in human breast cancer cells and induces an epithelial-mesenchymal transition (EMT) that is in part dependent on its ability to increase TGF-beta signaling
Micalizzi et al., Cancer Res 2010 (Breast Neoplasms...) : Importantly, Six1 induced EMT and metastasis are dependent on TGF-ß signaling
Ono et al., Oncogene 2012 (Colorectal Neoplasms) : Using SW480 cells stably transfected with a SIX1 expression construct and their control counterparts, we demonstrated that SIX1 overexpression represses CDH1 expression and promotes EMT in CRC ... SIX1 induced CDH1 repression and EMT in CRC cells were correlated at least in part with posttranscriptional ZEB1 activation and miR-200-family transcriptional repression