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IGF2 — SMAD2

Text-mined interactions from Literome

Fanayan et al., J Biol Chem 2002 (Breast Neoplasms) : We previously demonstrated in T47D cells transfected to express the transforming growth factor-beta receptor type II ( TGF-betaRII ) that insulin-like growth factor binding protein-3 ( IGFBP-3 ) could stimulate Smad2 and Smad3 phosphorylation, potentiate TGF-beta1 stimulated Smad phosphorylation, and cooperate with exogenous TGF-beta1 in cell growth inhibition ( Fanayan, S., Firth, S. M., Butt, A. J., and Baxter, R. C. ( 2000 ) J. Biol. Chem. 275, 39146-39151 )
Kim et al., Arthritis Rheum 2010 : Upon combination treatment, IGF-1 activated Smad2 , while BMP-7 activated Smad1/5/8 and Smad3, thus inducing all Smad signaling pathways and mimicking the effects of the combination of transforming growth factor ß and BMP-7