Mooney et al., J Biol Chem 2001
(Insulin Resistance) :
SOCS-1 and SOCS-6 do not inhibit insulin dependent IR autophosphorylation, but both proteins inhibit insulin dependent activation of ERK1/2 and protein kinase B in vivo and IR-directed phosphorylation of IRS-1 in vitro
Bayle et al., J Biol Chem 2004
:
SOCS6 reduced SCF induced activation of ERK1/2 and p38 but not activation of AKT or STATs in Ba/F3, murine embryonic fibroblast (MEF), or COS-7 cells
Kazi et al., J Biol Chem 2012
:
The presence of SOCS6 also induces weaker activation of Erk1/2, but not Akt , in transfected Ba/F3 and UT-7 cells and in OCI-AML-5 cells