Gene interactions and pathways from curated databases and text-mining

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IFNG — SPHK2

Text-mined interactions from Literome

Aas et al., Cell communication & adhesion 2001 (Calcium Signaling) : Apparently, sphingosine kinase activity is also involved in IFN-gamma induced calcium signals
Yoshimoto et al., J Immunol 2003 : Ectopic expression of dominant negative SPHK2 in Th1 cell clone significantly reduced IL-12 induced IFN-gamma production, while that of wild-type SPHK2 enhanced it
Cheon et al., Biochem Biophys Res Commun 2008 : In this study, to elucidate whether SPHK is involved in IL-18 induced IFN-gamma production, we measured IL-18 induced IFN-gamma production after pre-treatment with SPHK inhibitor (SKI) in NK-92MI cells ... Inhibition of SPHK by SKI also inhibited IL-18 induced IFN-gamma production in human primary NK cells