Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Gao et al., Nature 2009 : Here we report that the c-Myc ( hereafter referred to as Myc ) oncogenic transcription factor , which is known to regulate microRNAs and stimulate cell proliferation, transcriptionally represses miR-23a and miR-23b, resulting in greater expression of their target protein, mitochondrial glutaminase, in human P-493 B lymphoma cells and PC3 prostate cancer cells
Yoo et al., Nature 2009 : Previous studies have indicated that miR-9* and miR-124 are repressed by the repressor-element-1 silencing transcription factor ( REST, also known as NRSF )
Reddy et al., Cancer Res 2009 (Neoplasms, Experimental) : We found that endogenous miR-661 expression was positively regulated by the c/EBPalpha transcription factor , which is down-regulated during cancer progression
Christoffersen et al., Cell Death Differ 2010 (Neoplasms) : Instead, upregulation of miR-34a is mediated by the ETS family transcription factor , ELK1
Ohdaira et al., Comput Biol Chem 2009 (Lung Neoplasms) : Using a luciferase reporter assay, we also showed that hsa-miR-601 specifically repressed nuclear factor-kappaB (NF-kappaB) transcription factor dependent reporter expression, a key component of the immune-oncogenesis pathway
Garofalo et al., Cancer Cell 2009 (Carcinoma, Non-Small-Cell Lung...) : Finally, we demonstrate that the MET oncogene is involved in miR-221 & 222 activation through the c-Jun transcription factor
Hu et al., Proc Natl Acad Sci U S A 2010 (Neuroblastoma) : Overexpression of the N-Myc transcription factor , an oncogene frequently amplified in neuroblastoma, induced miR-421 expression, which, in turn, down-regulated ATM expression, establishing a linear signaling pathway that may contribute to N-Myc induced tumorigenesis in neuroblastoma
Mardaryev et al., FASEB J 2010 : Microarray, qRT-PCR and Western blot analyses revealed that miR-31 negatively regulates expression of Fgf10, the components of Wnt and BMP signaling pathways Sclerostin and BAMBI, and Dlx3 transcription factor , as well as selected keratin genes, both in vitro and in vivo
Ponomarev et al., Nat Med 2011 (Encephalomyelitis, Autoimmune, Experimental...) : When overexpressed in macrophages, miR-124 directly inhibited the transcription factor CCAAT/enhancer binding protein-a ( C/EBP-a ) and its downstream target PU.1, resulting in transformation of these cells from an activated phenotype into a quiescent CD45 ( low ), major histocompatibility complex ( MHC) class II(low ) phenotype resembling resting microglia
Ren et al., Plant Sci 2012 : Sucrose induces the expression of miR398 and the production of miR398 is controlled by SQUAMOSA promoter binding protein-like7 ( SPL7 ) transcription factor under copper deficiency in Arabidopsis thaliana
Dong et al., RNA 2012 : Coat color determination by miR-137 mediated down-regulation of microphthalmia associated transcription factor in a mouse model
Nahid et al., J Immunol 2013 : The rapid induction of miR-132/-212 was transcription factor CREB dependent , and the sustained expression of miR-132/-212 was responsible for inducing tolerance to subsequent PGN challenge
Melo et al., Nat Cell Biol 2013 (Breast Neoplasms) : The GATA3 transcription factor is now shown to regulate the tumour microenvironment by inducing the expression of miR-29b in cancer cells
Shirasaki et al., J Virol 2013 (Carcinoma, Hepatocellular...) : Gene expression profiling of Huh-7.5 cells showed that miR-27a regulates lipid metabolism by targeting the lipid synthetic transcription factor RXRa and the lipid transporter ATP binding cassette subfamily A member 1
Gebeshuber et al., Nat Med 2013 (Glomerulosclerosis, Focal Segmental) : Mechanistically, miR-193a inhibits the expression of the Wilms' tumor protein ( WT1 ), a transcription factor and master regulator of podocyte differentiation and homeostasis