UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

IL6 — TIRAP

Pathways - manually collected, often from reviews:

OpenBEL Selventa BEL large corpus: IL6 → TIRAP (increases) Zhang et al., EMBO J 2006 *
Evidence: serine phosphorylation was crucial for TLR-induced interleukin 6 production

Text-mined interactions from Literome

Andreakos et al., Blood 2004 : We found that MyD88 and Mal/TIRAP are essential for LPS induced I kappa B alpha phosphorylation, NF-kappa B activation, and interleukin 6 (IL-6) or IL-8 production in fibroblasts and endothelial cells in a pathway that also requires IKK2 ... In contrast, in macrophages neither MyD88, Mal/TIRAP , nor I kappa B kinase 2 (IKK2) are required for NF-kappa B activation or tumor necrosis factor alpha (TNF alpha), IL-6 , or IL-8 production, although Mal/TIRAP is still involved in the production of interferon beta (IFN beta)
Sacre et al., Am J Pathol 2007 (Arthritis, Rheumatoid...) : In addition, overexpression of dominant negative forms of MyD88 and Mal/TIRAP significantly down-regulated the spontaneous production of cytokines tumor necrosis factor-alpha, IL-6 , and vascular endothelial growth factor, and enzymes MMP-1, MMP-2, MMP-3, and MMP-13 in RA synovial membrane cell cultures