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IL2 — TLR1

Text-mined interactions from Literome

Radoja et al., J Immunol 2001 : In response to TCR ligation of nonlytic TIL in vitro, proximal and distal signaling events are normal ; calcium flux is rapid ; mitogen activated protein/extracellular signal related kinase kinase, extracellular regulatory kinase 2, phosphoinositide-3 kinase, and protein kinase C are activated ; and IL-2 and IFN-gamma is secreted
Ridolfi et al., J Eur Acad Dermatol Venereol 2001 (Melanoma...) : Administration of granulocyte macrophage-colony stimulating factor ( GM-CSF ) may lead to APC recovery and interleukin (IL)-2 may restore local TIL activation
Correale et al., Br J Cancer 2001 (Bone Neoplasms...) : In this model, we investigated the in vitro possibility of generating an efficient PTH-rP specific CTL response by cyclical stimulations with IL-2 and PTR-4 peptide pulsed autologous dendritic cells ( DC ), of HLA-A2.1 ( + ) tumour infiltrating lymphocytes (TIL) derived from a patient with metastatic prostate carcinoma
Salmeron et al., Cancer Immunol Immunother 1992 (Melanoma) : Uncultured TIL produced interferon gamma (IFN gamma), but not interleukin-2 (IL-2) or IL-4, in response to anti-CD3 mAb or IL-2 ... In bulk cultures, IL-2 activated TIL displaying autologous tumor-specific cytotoxicity ( CTL-TIL ) produced IFN gamma in culture with medium alone, whereas IL-2 activated noncytotoxic TIL did not ... Addition of anti-CD3 mAb or autologous tumor cells up-regulated IFN gamma production in IL-2 activated TIL from 10 of 12 or 6 of 12 cases respectively ... Anti-CD3 mAb was required for IL-4 production in 3 of 12 IL-2 activated TIL , 2 of 6 CTL clones, and none of 5 noncytotoxic TIL clones
Teichmann et al., Leuk Res 1992 (Leukemia) : Adoptive immunotherapy with interleukin 2-induced lymphokine activated killer ( LAK ) cells or tumor infiltrating lymphocytes (TIL) and the induction of anti-tumor responses by IL-2 alone having proven to be promising approaches in cancer therapy
Kramer et al., J Leukoc Biol 2006 (Crohn Disease) : Moreover, they lack MDP induced enhancement of TLR mediated tumor necrosis factor alpha, interleukin (IL)-12 , and IL-10 production, which is observed in control DC with intact NOD2
De Felice et al., Tissue Antigens 1990 : On the other hand, MoAb CLB-CD28/1 induces response to IL-2 in thymocytes in the absence of accessory cells
Allam et al., J Allergy Clin Immunol 2008 : Moreover, TLR4-ligation on oLCs induced IL-10, TGF-beta1, Forkhead box protein 3, IFN-gamma, and IL-2 production in T cells
Mansfield et al., Cancer Immunol Immunother 1991 (Melanoma) : These results suggest that use of HC antibody in vivo would be more advantageous than anti-CD3 mAb, with regard to augmentation of IL-2 induced TIL activation
Platsoucas et al., Cancer Metastasis Rev 1991 (Melanoma) : T cell lines and clones with autologous tumor-specific activity have been developed in malignant melanoma by stimulating peripheral blood lymphocytes ( PBL ), lymph node lymphocytes or tumor infiltrating lymphocytes (TIL) with autologous melanoma cells in the presence of recombinant interleukin 2 ( rIL2 )
Lee et al., J Parasitol 2010 : We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether TLR and MUC expression is regulated by interferon (IFN)-gamma, interleukin-4 , or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen
Han et al., Vet Microbiol 2010 : Involvement of TLR21 in baculovirus induced interleukin-12 gene expression in avian macrophage-like cell line HD11
Piconi et al., AIDS 2010 (HIV Infections) : Activated T cells ( Ki67 ( + ) ), Treg lymphocytes ( CD4 ( + ) /CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression, interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V, activation of caspases 8 and 9, Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed
Chung et al., J Infect Dis 2010 (Hepatitis C, Chronic) : Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of interleukin 17 by naive CD4 ( + ) T cells in the presence of TLR ligands
Vaccarello et al., Hum Immunol 1990 (Ovarian Neoplasms) : The RNA message for interferon gamma was detected by in situ hybridization in TIL induced with interleukin 2 and tumor necrosis factor alpha but not in freshly isolated TIL
Schoof et al., Cancer Res 1990 (Neoplasms) : Finally, TIL could be induced to secrete IL-2 following solid-phase activation with anti-CD3
Hanamsagar et al., Trends Immunol 2012 : TLR signaling triggers the transcriptional activation of pro-interleukin-1ß ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome
Li et al., eLife 2012 : A sequence containing 13 nucleotides near the active site of 23S rRNA ribozyme, which catalyzes peptide bond synthesis, was both necessary and sufficient to trigger TLR13 dependent interleukin-1ß production
Koblansky et al., Immunity 2013 (Genetic Predisposition to Disease...) : Toll-like receptor 11 ( TLR11 ) recognizes T. gondii profilin ( TgPRF ) and is required for interleukin-12 production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice
Schamber-Reis et al., J Biol Chem 2013 (Disease Resistance...) : Altogether, our results indicate the redundant and essential role of nucleic acid sensing TLR3, TLR7 and TLR9 in inducing interleukin 12, development of a T1 response, and resistance to L. major infection in resistant C57BL/6 mice
Santegoets et al., Journal of translational medicine 2013 : Here, we have compared the effects of IL-2 , -15 and -21 cytokines on the expansion and activation of TIL from single-cell suspensions of non-small cell lung cancer, ovarian cancer and melanoma
Larruskain et al., Comp Immunol Microbiol Infect Dis 2013 : Sheep with lung lesions showed differential expression in five target genes : CCR5, TLR7 , and TLR8 were up regulated and IL2 and TNFa down regulated
Ames et al., Cancer Immunol Immunother 1989 (Adenocarcinoma...) : Cells harvested from LAK cell cultures and further enriched by centrifugation through a discontinuous Percoll gradient and interleukin-2 (IL-2) stimulated TIL demonstrated the highest levels of cytotoxicity, while total splenocytes and fresh TIL were characterized by the lowest levels ... Since IL-2 stimulated TIL were highly cytotoxic and exhibited better tumor localization than both NK cells and LAK cells in this system, they may be the lymphoid effectors of choice for adoptive immunotherapy of advanced cancer
Anderson et al., Cancer Immunol Immunother 1987 (Lung Neoplasms) : We also studied TIL and PBL LAK activity using the NK-resistant M14 target cells and determined the TIL response to IL-2 , plus IFN-gamma
Hori et al., Nihon Geka Gakkai Zasshi 1984 (Carcinoma...) : [ Tumor-specific cytotoxicity of tumor infiltrating lymphocytes (TIL) induced with TCGF in murine mammary carcinoma ]
Savelieva et al., J Immunother Emphasis Tumor Immunol 1994 (Adenocarcinoma...) : To analyze the effect of IL-2 on TIL , we next compared the data obtained in IL-2 treated versus nontreated patients
Ochalek et al., Int J Cancer 1994 (Colorectal Neoplasms) : No restriction of lymphocyte activity was found when the susceptibility of tumor cells to the panel of autologous and allogeneic Il-2 stimulated PBL ( LAK cells ) and TIL was compared
Lüscher et al., Int J Cancer 1994 (Brain Neoplasms...) : A primary tumor cell line was generated and cultured TIL were induced to transcribe IL-2 and IFN-gamma genes by incubation with the autologous irradiated tumor cell line, but not with autologous EBV transformed cells
Pross et al., Nat Immun 1993 (Neoplasms) : Nevertheless, NK cells among IL-2 activated TIL mediate antitumor cytotoxicity
Alexander et al., Cancer Res 1993 (Carcinoma, Renal Cell...) : In contrast to the lack of proliferative activity, stimulation of T-TIL or peripheral blood lymphocytes with phytohemagglutinin or anti-CD3 resulted in comparable levels of both IL2 and gamma-interferon mRNA and protein expression
Sica et al., Int J Cancer 1993 (Carcinoma, Renal Cell...) : These results illustrate that IL7 can potentiate the growth and production of IFN gamma from RCC-reactive TIL and, to a lesser extent, enhance IL2 induced LAK activity of TIL
Gohara et al., Jpn J Cancer Res 1997 (Adenocarcinoma...) : To cast light on T cell mediated specific immunity at the tumor site of colon cancer, we investigated whether interleukin-2 (IL-2) activated tumor infiltrating lymphocytes (TIL) from colon cancer show histocompatibility leukocyte antigen ( HLA ) -class I-restricted cytotoxicity against adenocarcinoma ... Furthermore, HLA-A31 restricted CTL activity was found in IL-2 activated TIL from one of two HLA-A31+ patients, suggesting the existence of HLA-class I-restricted CTL involving an allele other than A24
Suekane et al., Jpn J Cancer Res 1997 (Carcinoma, Embryonal...) : To understand T cell mediated specific immunity at the tumor site of testicular embryonal cancer, we investigated whether interleukin-2 (IL-2) activated tumor infiltrating lymphocytes (TIL) of a patient with testicular embryonal cancer show histocompatibility leukocyte antigen ( HLA ) -class I-restricted and tumor-specific cytotoxicity