Gene interactions and pathways from curated databases and text-mining

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IFNG — TLR5

Text-mined interactions from Literome

Pai et al., Infect Immun 2004 : Microarray gene expression studies were then used to determine whether prolonged TLR signaling by M. tuberculosis broadly inhibits IFN-gamma regulation of macrophage gene expression
Ortega-Cava et al., Clinical and vaccine immunology : CVI 2006 (Colitis...) : Finally, IFN-gamma may be involved in down regulating TLR5 expression
Mueller et al., J Immunol 2006 : The down-regulatory effect of Th2 cytokines on TLR expression and function in IECs also counteracted enhanced TLR signaling induced by stimulation with the hallmark Th1 cytokine IFN-gamma
Eriksson et al., J Immunol 2006 : However, purified uNK cells did not respond directly to TLR agonists, but IFN-gamma was produced by uNK cells in response to TLR stimulation when cocultured with APCs
Velayudham et al., J Hepatol 2006 (Granuloma...) : IFNgamma induction by P. acnes, TLR2 and TLR9 ligands required MyD88
Ramakers et al., Cytokine 2006 : In more detail, CPA potentiated TLR5 mediated IL-6 production, TLR3 mediated IFN-gamma production and TLR3 mediated Il-1beta production compared to TLR4 mediated stimulation
Girart et al., J Immunol 2007 (Melanoma) : Engagement of TLR3, TLR7 , and NKG2D regulate IFN-gamma secretion but not NKG2D mediated cytotoxicity by human NK cells stimulated with suboptimal doses of IL-12
Barr et al., Eur J Immunol 2007 : In this study, we investigated which mouse B cell subsets are the most potent cytokine producers, and examined the role of Toll-like receptors ( TLR ) in the control of secretion of IL-6, IL-10, IL-12 and IFN-gamma by B cells ... Thus, in response to combined TLR stimulation, or via phorbol esters, IFN-gamma was secreted
Allam et al., J Allergy Clin Immunol 2008 : Moreover, TLR4-ligation on oLCs induced IL-10, TGF-beta1, Forkhead box protein 3, IFN-gamma , and IL-2 production in T cells
O'Mahony et al., International journal of medical sciences 2008 : Of the cytokines examined, IFN-gamma and GM-CSF caused the greatest effects on TLR expression
Prescott et al., J Allergy Clin Immunol 2008 (Hypersensitivity...) : Maternal allergy ( n = 59 ) was associated with significantly higher neonatal IL-12 and IFN-gamma responses to TLR2, TLR3 , and TLR4 activation, whereas TNF-alpha and IL-6 responses to TLR2, TLR4, and TLR5 activation were significantly higher in newborns who subsequently had allergic disease ( n = 32 )
Archer et al., Cell Microbiol 2009 : Thus, MyD88 dependent innate immune responses induced by L. pneumophila involve both TLR dependent responses and IL-18R dependent production of IFN-gamma by natural killer cells, and these MyD88 dependent pathways can function independently to provide host protection against an intracellular pathogen
Yarovinsky et al., J Immunol 2008 (Acute Disease...) : We further show that this immunopathology is the result of non-TLR dependent activation of IFN-gamma secretion by NK cells in response to the infection
Lotter et al., PLoS Pathog 2009 (Disease Models, Animal...) : IFN-gamma production by NKT cells requires the presence of CD1d and simultaneously TLR receptor signalling through MyD88 and secretion of IL-12
Devilder et al., J Immunol 2009 : Moreover TLR induced Vgamma9Vdelta2 IFN-gamma noncytolytic response led to efficient DC polarization into IL-12p70 producing cells
Lee et al., J Parasitol 2010 : We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether TLR and MUC expression is regulated by interferon (IFN)-gamma , interleukin-4, or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen
van Hoffen et al., Int Arch Allergy Immunol 2010 : Apically added LGG, TLR2 and NOD2 ligands, but not Bb, enhanced IFN-gamma , IL-12 and/or TNF-alpha secretion
Fang et al., FEMS Immunol Med Microbiol 2010 (West Nile Fever) : Viral antigens were detected in WNV infected gammadelta T cells.WNV infection or toll-like receptor ( TLR ) agonist treatment of gammadelta T cells induced the production of IFN-gamma , tumor necrosis factor-alpha and IL-6, which are known to promote DC maturation
Brisbin et al., Benef Microbes 2012 : The results demonstrated that chicken CD4+ and CD8+ T-cells express TLR21 and that the various isolates of lactobacilli differentially induces the expression of interleukin 10, interferon-gamma and transforming growth factor beta