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MAPK8 — TLR9

Text-mined interactions from Literome

Jiang et al., J Biol Chem 2003 (MAP Kinase Signaling System) : However, we find that, in response to dsRNA, TLR3 can mediate the activation of both NFkappaB and mitogen activated protein ( MAP ) kinases in IL-1-unresponsive mutant cell lines, including IRAK-deficient I1A and I3A cells, which are defective in a component that is downstream of IL-1R but upstream of IRAK
Salojin et al., J Immunol 2006 (Arthritis, Experimental...) : MKP-1-deficient macrophages also show enhanced constitutive and TLR induced activation of p38 MAPK
Chi et al., Proc Natl Acad Sci U S A 2006 (Shock, Septic) : Thus, p38 MAPK plays a critical role in mediating IL-10 synthesis in TLR signaling
Moeinpour et al., Mol Immunol 2007 (Hemorrhage...) : Inflammatory mediators, Toll-like receptor ( TLR ) and myeloid differentiation adaptor protein ( MyD88 ) expression, and the activation of mitogen activated protein kinase ( MAPK ) were determined
Lim et al., Exp Mol Med 2007 : Toll-like receptor 9 dependent activation of MAPK and NF-kB is required for the CpG ODN induced matrix metalloproteinase-9 expression ... Taken together, our data demonstrate that CpG ODN triggers MMP-9 expression via TLR-9 dependent ERK and p38 MAPK activation followed by NF-kappaB activation
Banerjee et al., Immunol Cell Biol 2007 : Toll-like receptor ( TLR ) signaling leads to the activation of mitogen activated protein kinase and nuclear factor-kappaB signaling pathways
El Kebir et al., Arch Immunol Ther Exp (Warsz) 2008 (Bacterial Infections) : TLR9 stimulation results in alterations in cellular redox balance, peroxynitrite formation, activation of the mitogen activated protein kinase , PI3-kinase, and Jun N-terminal kinase pathways and/or nuclear factor kappaB and AP-1
Peña et al., Inflamm Bowel Dis 2009 (Disease Models, Animal...) : TLR9 activation of BMDCs induces sustained p38 MAPK activation and greater Th1- and Th17-type cytokine secretion in both strains of Galpha(i)2-deficient compared to wildtype BMDCs
Park et al., J Immunol 2009 : Protein kinase D1 (PKD1) has been shown to be involved in certain MAPK activation and cytokine expression by several TLR ligands
He et al., PloS one 2011 : In addition, morphine treatment failed to induce an increased levels of phosphorylated p38 MAPK and MAP kinase kinase 3/6 ( MKK3/6 ), the upstream MAPK kinase of p38 MAPK, in either TLR9 deficient or µ-opioid receptor ( µOR ) deficient primary microglia, suggesting an involvement of MAPK and µOR in morphine mediated TLR9 signaling
Yang et al., Infect Immun 2011 (Plague) : Analysis of this network showed that signaling pathways important for host immune responses were preferentially targeted by Y. pestis, including the pathways involved in focal adhesion, regulation of cytoskeleton, leukocyte transendoepithelial migration, and Toll-like receptor ( TLR ) and mitogen activated protein kinase ( MAPK ) signaling
Song et al., Toxicol Pathol 2012 : The regulatory effect of complement on TLR signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and involved increased mitogen activated protein kinase and nuclear factor ?B activation
Yee et al., Eur J Immunol 2013 : ß2 integrins inhibit TLR responses by regulating NF-?B pathway and p38 MAPK activation
de Almeida et al., Infect Immun 2013 (Brucellosis...) : Furthermore, our findings demonstrated that the mitogen activated protein kinase ( MAPK ) signaling pathway is impaired in TLR2, TLR6 , and TLR2/6 knockout ( KO ) DCs when infected with B. abortus, which may account for the lower proinflammatory cytokine production observed in TLR6 KO mouse dendritic cells
Dimitrakopoulos et al., Microbes Infect 2013 : B. melitensis caused a delayed, TLR2 dependent MAPK activation