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TNF — TRAF6
Pathways - manually collected, often from reviews:
-
BioCarta nf-kb signaling pathway:
TNF/TNF R/FADD/TRADD/RIP/TRAF6 complex (TNF-TNFRSF1A-FADD-TRADD-RIPK1-TRAF6)
→
IKK-alpha/MEKK1/NIK complex (CHUK-MAP3K1-MAP4K4)
(modification, activates)
-
BioCarta nf-kb signaling pathway:
TNF-alpha (TNF)
→
TNF R/FADD/TRADD/RIP/TRAF6 complex (TNFRSF1A-FADD-TRADD-RIPK1-TRAF6)
(modification, collaborate)
-
BioCarta nf-kb signaling pathway:
TNF-alpha (TNF)
→
TNF/TNF R/FADD/TRADD/RIP/TRAF6 complex (TNF-TNFRSF1A-FADD-TRADD-RIPK1-TRAF6)
(modification, collaborate)
-
BioCarta nf-kb signaling pathway:
TNF R/FADD/TRADD/RIP/TRAF6 complex (TNFRSF1A-FADD-TRADD-RIPK1-TRAF6)
→
TNF/TNF R/FADD/TRADD/RIP/TRAF6 complex (TNF-TNFRSF1A-FADD-TRADD-RIPK1-TRAF6)
(modification, collaborate)
-
WikiPathways Photodynamic therapy-induced NF-kB survival signaling:
TNF/TNFRSF1A
→
TRAF6
(activation)
Text-mined interactions from Literome
Pryhuber et al., Am J Respir Cell Mol Biol 2000
(Pneumonia) :
In contrast to the epithelial cells,
TRAF1 was not
induced by
TNF-alpha in U937 cells, a human monocytic cell line, suggesting cell type-specific regulation
Caunt et al., J Biol Chem 2001
:
Ras controls
tumor necrosis factor receptor associated factor (
TRAF)6 dependent induction of nuclear factor-kappa b. Selective regulation through receptor signaling components
Ichikawa et al., Biochem Biophys Res Commun 2006
:
While TNF-alpha exerts various biological effects including cell death, the
role of
TRAF6 in the
TNF-alpha signaling remains to be unclear
Shembade et al., EMBO J 2009
:
RNF11 negatively regulated RIP1 and
TRAF6 ubiquitination upon
stimulation with
TNF and LPS, respectively
Avila et al., Innate Immun 2012
:
Our results indicate that Lyn plays a positive role in TLR4 induced production of
TNF-a in MCs
controlling the activity of the
TRAF-6/TAK-1 protein complex
Min et al., J Immunol 1997
:
These data suggest that
TNF activates parallel
TRAF-NF-kappa B and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways to initiate E-selectin transcription