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RELA — TNFRSF11B
Text-mined interactions from Literome
Min et al., J Exp Med 2000
(Calcinosis...) :
Although
OPG is normally expressed in arteries, OPG ligand (OPGL) and receptor activator of
NF-kappaB ( RANK ) are not
detected in the arterial walls of wild-type adult mice
Van Bezooijen et al., Bone 2001
(Bone Resorption) :
To further examine the pathway by which osteoclastic resorption was stimulated, we used
osteoprotegerin , a specific
inhibitor of the receptor activator of
NF-kappaB ( RANK ) /receptor activator of the NF-kappaB ligand ( RANKL ) pathway
Kobayashi-Sakamoto et al., Biochem Biophys Res Commun 2004
:
NF-kappaB dependent induction of
osteoprotegerin by Porphyromonas gingivalis in endothelial cells ... P. gingivalis induced NF-kappaB activation, and the induction of
OPG in HMVEC by the pathogen was
blocked by the inhibitors of
NF-kappaB
Zheng et al., J Biol Chem 2006
(Bone Resorption) :
This response was time- and dose dependent, required
NF-kappaB activation and new protein synthesis, and was specifically
blocked by the RANKL decoy receptor
osteoprotegerin
Nakamichi et al., J Immunol 2007
(Bone Resorption) :
Osteoprotegerin reduces the serum level of receptor activator of
NF-kappaB ligand derived from osteoblasts
Lambert et al., J Bone Miner Res 2007
:
In contrast,
NF-kappaB was not
essential for IL-1beta induction of
OPG
Reid et al., Molecular cancer 2009
(Breast Neoplasms...) :
These increases in endothelial cell
OPG secretion were
dependent on alphanubeta3 ligation and
NFkappaB activation