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INS — TXNIP

Text-mined interactions from Literome

Shaked et al., Diabetologia 2009 (Diabetes Mellitus, Type 2) : Since hyperglycaemia leads to elevated serum insulin, we hypothesised that insulin is involved in the regulation of TXNIP protein levels in beta cells ... Inhibition of glucose and fatty acid stimulated insulin secretion with diazoxide increased TXNIP production in beta cells ... Nitric oxide ( NO ), a repressor of TXNIP, enhanced insulin signal transduction, whereas inhibition of NO synthase abolished its activation, suggesting that TXNIP inhibition by NO is mediated by stimulation of insulin signalling ... Repression of TXNIP by insulin is probably an important compensatory mechanism protecting beta cells from oxidative damage and apoptosis in type 2 diabetes
Mogami et al., Pediatr Res 2010 (Disease Models, Animal...) : Thioredoxin binding protein-2 inhibits excessive fetal hypoglycemia during maternal starvation by suppressing insulin secretion in mice
Masutani et al., Journal of clinical biochemistry and nutrition 2012 : Enhancement of thioredoxin binding protein -2 expression causes impairment of insulin sensitivity and glucose induced insulin secretion, and ß-cell apoptosis
Robinson et al., J Mol Endocrinol 2013 : Degradation of Txnip occurred within 15 ?min in the presence of 3 ?nM insulin and overnight with 0.6 ?nM insulin
Xu et al., Nat Med 2013 (Diabetes Mellitus, Experimental) : Thioredoxin interacting protein regulates insulin transcription through microRNA-204 ... Taken together, our results demonstrate that TXNIP controls microRNA expression and insulin production and that miR-204 is involved in beta-cell function