Gene interactions and pathways from curated databases and text-mining

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EGFR — TYR

Text-mined interactions from Literome

Simeonova et al., J Biol Chem 2002 (MAP Kinase Signaling System...) : The EGFR phosphorylation by arsenic is ligand independent and does not involve the major autophosphorylation site Tyr ( 1173 )
Mifune et al., Am J Physiol Cell Physiol 2004 : We found that BTC stimulated phosphorylation of EGF receptor (EGFR) at Tyr1068 , which was completely blocked by an EGFR kinase inhibitor, AG-1478
Yin et al., J Biol Chem 2005 (Neoplasm Metastasis) : Epidermal growth factor (EGF) receptor activation resulted in Tyr phosphorylation of PG, which was accompanied by a loss of desmoplakin from desmosomes and decreased adhesive strength following 18-h EGF treatment
RittiƩ et al., Am J Pathol 2007 (Carcinoma, Basal Cell...) : Although total ErbB1 protein and mRNA were similar in cancerous and normal skin, we found that ErbB1 activation ( phospho-Tyr ( 1068 ) ) was greater in bulk SCC versus BCC or normal skin
Dittmann et al., Radiother Oncol 2007 (Carcinoma, Bronchogenic...) : At the molecular level P-Tyr mediated a general phosphorylation of EGFR and a pronounced phosphorylation of nuclear EGFR at residue Thr No. 654, also observed after treatment with ionizing radiation
Cai et al., Am J Physiol Cell Physiol 2010 (Vascular Diseases) : These events involved epidermal growth factor receptor dependent PKC-delta redox-sensitive Tyr-311 and Tyr-332 phosphorylation and were suppressed in AGER1 ( + ) ECs and enhanced in sh-mRNA-AGER1 ( + ) ECs
Luna et al., Biol Reprod 2012 (MAP Kinase Signaling System) : Western blot analysis confirmed both that EGFR is in the active form and that phosphorylation of Tyr845 increased after incubation with EGF
Waitkus et al., J Biol Chem 2013 : EGFR activation induces classical STAT3 Tyr ( 705 ) phosphorylation but also initiates an inhibitory signal through the PI3K-AKT signaling axis that prevents STAT3 Ser ( 727 ) phosphorylation
Mishra et al., Carcinogenesis 1993 (Breast Neoplasms) : Orthovanadate ( 100 microM for 4 h ) inhibited this decrease, implicating the role of cellular PTPase in P-Tyr mediated control of EGFR tyrosine phosphorylation