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EGFR — TYR
Text-mined interactions from Literome
Simeonova et al., J Biol Chem 2002
(MAP Kinase Signaling System...) :
The
EGFR phosphorylation by arsenic is ligand independent and does not
involve the major autophosphorylation site
Tyr ( 1173 )
Mifune et al., Am J Physiol Cell Physiol 2004
:
We found that BTC stimulated phosphorylation of EGF receptor (EGFR) at
Tyr1068 , which was completely
blocked by an
EGFR kinase inhibitor, AG-1478
Yin et al., J Biol Chem 2005
(Neoplasm Metastasis) :
Epidermal growth factor (EGF) receptor activation
resulted in
Tyr phosphorylation of PG, which was accompanied by a loss of desmoplakin from desmosomes and decreased adhesive strength following 18-h EGF treatment
RittiƩ et al., Am J Pathol 2007
(Carcinoma, Basal Cell...) :
Although total ErbB1 protein and mRNA were similar in cancerous and normal skin, we found that
ErbB1 activation (
phospho-Tyr ( 1068 ) ) was greater in bulk SCC versus BCC or normal skin
Dittmann et al., Radiother Oncol 2007
(Carcinoma, Bronchogenic...) :
At the molecular level
P-Tyr mediated a general phosphorylation of
EGFR and a pronounced phosphorylation of nuclear EGFR at residue Thr No. 654, also observed after treatment with ionizing radiation
Cai et al., Am J Physiol Cell Physiol 2010
(Vascular Diseases) :
These events involved
epidermal growth factor receptor dependent PKC-delta redox-sensitive
Tyr-311 and Tyr-332 phosphorylation and were suppressed in AGER1 ( + ) ECs and enhanced in sh-mRNA-AGER1 ( + ) ECs
Luna et al., Biol Reprod 2012
(MAP Kinase Signaling System) :
Western blot analysis confirmed both that
EGFR is in the active form and that phosphorylation of
Tyr845 increased after incubation with EGF
Waitkus et al., J Biol Chem 2013
:
EGFR activation
induces classical STAT3
Tyr ( 705 ) phosphorylation but also initiates an inhibitory signal through the PI3K-AKT signaling axis that prevents STAT3 Ser ( 727 ) phosphorylation
Mishra et al., Carcinogenesis 1993
(Breast Neoplasms) :
Orthovanadate ( 100 microM for 4 h ) inhibited this decrease, implicating the role of cellular PTPase in
P-Tyr mediated control of
EGFR tyrosine phosphorylation