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VEGFA — VHL

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: VEGFA → VHL (decreases)
  Evidence: Furthermore, the re-introduction of a degradation-resistant mutant of HIF-2a into RCC cells ectopically expressing pVHL abolishes the ability of VHL to suppress the growth of these cell lines [21]. VHL AS A MULTI-FACETED TUMOUR SUPPRESSOR Enhanced cell proliferation Several polypeptide growth factors that stimulate the proliferation of normal cells have pathological consequences for tumourigenesis when deregulated. RCC cells lacking functional pVHL overexpress various growth factors, including p...

Text-mined interactions from Literome

Brieger et al., J Mol Med (Berl) 1999 (Carcinoma, Renal Cell...) : The upregulation of VEGF has been shown in vitro as a consequence of alteration of the VHL gene
Liu et al., Cancer Res 2003 (Carcinoma, Renal Cell...) : By analogy to human RCC in which mutations in the von Hippel-Lindau (VHL) tumor suppressor gene result in accumulation of hypoxia-inducible factor alpha ( HIFalpha ) and up-regulation of vascular endothelial growth factor ( VEGF ), we investigated the regulation of HIF and its target gene VEGF in rat RCC resulting from Tsc-2 defects
Na et al., EMBO J 2003 (Kidney Neoplasms...) : pVHL can also suppress hsRPB7 induced VEGF promoter transactivation, mRNA expression and VEGF protein secretion ... Together, our results suggest that hsRPB7 is a downstream target of the VHL ubiquitylating complex and pVHL may regulate angiogenesis by targeting hsRPB7 for degradation via the ubiquitylation pathway and preventing VEGF expression
Datta et al., Oncogene 2005 (Carcinoma, Renal Cell...) : VHL not only inhibits the transcription of VPF/VEGF but also plays a significant role in decreasing its mRNA stability
Theilig et al., Am J Pathol 2011 (Anti-Glomerular Basement Membrane Disease...) : Tubular VHL knockout and, thus, local HIF-a stabilization increased renal production of vascular endothelial growth factor , tumor growth factor-ß ( 1 ), and platelet derived growth factor-B, resulting in augmented formation of capillaries and interstitial matrix, and conversion of fibroblasts to myofibroblasts
Kurihara et al., J Cell Biol 2011 : Combinatorial gene deletion involving Vhl, Hif-as, and Vegf genes revealed that HIF-2a/vascular endothelial growth factor signaling induces secondary outgrowth in Vhl mutants
Reynoso-Roldán et al., Clin Invest Med 2012 (Anoxia...) : Although HIF-1alpha is constitutively expressed in normal keratinocytes, it is not known if HDAC1 and VHL can regulate VEGF production in these cells
Mukhopadhyay et al., Mol Cell Biol 1997 : We have therefore assessed the effect of the VHL gene product on VEGF expression ... Furthermore, endogenous VEGF mRNA levels were suppressed in permanent RCC cell lines expressing wt-VHL, and nuclear run-on studies indicated that VHL regulation of VEGF occurs at least partly at the transcriptional level
Pal et al., J Biol Chem 1997 (Carcinoma, Renal Cell...) : The present study investigated the pathways by which VHL regulates VPF/VEGF expression