Jackson et al., Bone 2005
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Importantly, Wnt3a induces the expression of osteoprotegerin by a beta-catenin dependent mechanism indicating that the Wnt pathway may also affect osteoclastogenesis
Sato et al., Genes Cells 2009
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Bone morphogenetic protein-2 enhances Wnt/beta-catenin signaling induced osteoprotegerin expression ... OPG expression was induced by Wnt/beta-catenin signaling in C2C12 cells and osteoblastic MC3T3-E1 cells ... Deletion and mutation analysis revealed that Wnt/beta-catenin signaling regulates transcription of OPG via a promoter region containing two Wnt/beta-catenin responsive sites ... BMP-2 enhanced Wnt/beta-catenin dependent transcriptional activation of the OPG promoter