Gene interactions and pathways from curated databases and text-mining

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MAPK8 — XIAP

Text-mined interactions from Literome

Dai et al., Mol Cell Biol 2005 (Leukemia) : Inhibition of NF-kappaB by pharmacological inhibitors or genetic strategies markedly potentiated apoptosis induced by HDACIs, and this was accompanied by enhanced reactive oxygen species ( ROS ) generation, downregulation of Mn-superoxide dismutase and XIAP , and c-Jun N-terminal kinase 1 ( JNK1 ) activation
Kaur et al., J Biol Chem 2005 (Carcinoma, Hepatocellular) : X-linked inhibitor of apoptosis (XIAP) inhibits c-Jun N-terminal kinase 1 ( JNK1 ) activation by transforming growth factor beta1 ( TGF-beta1 ) through ubiquitin mediated proteosomal degradation of the TGF-beta1 activated kinase 1 (TAK1)
Cipak et al., Neoplasma 2012 (Leukemia...) : Inhibitors of JNK ( SP600125 ) and p38 MAPK ( SB203580 ) suppressed HEAMQ induced apoptosis and G2/M phase arrest, attenuated the activation of Bax, and blocked down-regulation of Bcl-2, XIAP and survivin in HEAMQ treated U937 cells
Fadó et al., Scientific reports 2013 (MAP Kinase Signaling System) : The effects of XIAP are mediated by the mitogen activated protein kinase ( MEK ) /extracellular signal regulated kinases ( ERKs ) pathway since blocking this pathway completely prevents the neuritogenesis mediated by XIAP downregulation