Ichiki et al., Arterioscler Thromb Vasc Biol 2001
:
Overexpression of dominant negative Rho A also suppressed AT(1)-R mRNA expression
Hidaka et al., Am J Pathol 2008
(Glomerulonephritis) :
The small GTPase RhoA is activated by the angiotensin II (AngII) type 1 receptor ( AT1R ), which is part of the local renin-angiotensin system that is involved in podocyte injury preceding glomerular crescent formation
Bregeon et al., Am J Physiol Cell Physiol 2009
:
Nevertheless, the mechanisms leading to RhoA activation by AT1R are unknown ... Using siRNA and mutant overexpression, we then demonstrate that the tyrosine phosphatase SHP2 is necessary for 1 ) maintaining p190A basally phosphorylated and activated by the tyrosine kinase c-Abl, and 2 ) inducing p190A dephosphorylation and RhoA activation in response to AT1R activation