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AKT1 — SFN

Pathways - manually collected, often from reviews:

• NCI Pathway Database a6b1 and a6b4 Integrin signaling: AKT1 (AKT1) → 14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB) (modification, activates)
  Santoro et al., Dev Cell 2003
  Evidence: assay, physical interaction
• NCI Pathway Database a6b1 and a6b4 Integrin signaling: AKT1 (AKT1) → Ron/MSP/14-3-3 family complex (MST1R-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB-MST1) (modification, activates)
  Santoro et al., Dev Cell 2003
  Evidence: assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: AKT1 — SFN (association, coimmunoprecipitation) Calvo et al., Biochim Biophys Acta 2010*

Text-mined interactions from Literome

Moon et al., Cancer Lett 2010 (Carcinoma, Hepatocellular...) : SFN also suppressed the phosphorylation of Akt ( Ser-473 ), thereby inhibiting hTERT phosphorylation and this effect was reversed by pretreatment with NAC
Roy et al., Journal of molecular signaling 2010 : SFN inhibited phosphorylation of AKT and ERK, and activated FOXO transcription factors, leading to cell cycle arrest and apoptosis