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ANGPT1 — IL8
Text-mined interactions from Literome
Pizurki et al., Br J Pharmacol 2003
:
Angiopoietin-1 inhibits endothelial permeability, neutrophil adherence and
IL-8 production
Abdel-Malak et al., Blood 2008
:
Ang-1 elicited in human umbilical vein endothelial cells ( HUVECs ) a dose- and time dependent increase in IL-8 production as a result of induction of mRNA and
enhanced mRNA stability of
IL-8 transcripts ... Upstream from the AP-1 complex,
up-regulation of
IL-8 transcription by
Ang-1 was mediated through the Erk1/2, SAPK/JNK, and PI-3 kinase pathways, which triggered c-Jun phosphorylation on Ser63 and Ser73
Choe et al., Joint Bone Spine 2012
(Arthritis, Rheumatoid...) :
Tacrolimus ( FK506 ) inhibits
interleukin-1ß induced
angiopoietin-1 , Tie-2 receptor, and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes
Neagoe et al., J Cell Physiol 2012
:
Angiopoietin-1 but not angiopoietin-2
induces IL-8 synthesis and release by human neutrophils