Zamo et al., Oncogene 2002
(Lymphoma, Large-Cell, Anaplastic) :
NPM-ALK expression caused enhanced Bcl-x ( L ) transcription, largely mediated by Stat3
Coluccia et al., Blood 2004
(Lymphoma, Large B-Cell, Diffuse) :
In this report, the NPM/ALK mediated induction of Bcl-XL ( but not of Bcl-2 ) was identified in human ALCL derived cells ... NPM/ALK kinase activity was required to promote Bcl-XL expression and its protective effect on mitochondrial homeostasis