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BIRC2 — RELA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Uzzo et al., Clin Cancer Res 2002
(Prostatic Neoplasms) :
In this study, we demonstrate by immunoblotting and immunohistochemistry that physiological levels of zinc inhibit activation of
nuclear factor (NF)-kappa B transcription factor in PC-3 and DU-145 human prostate cancer cells,
reduce expression of NF-kappa B-controlled antiapoptotic protein
c-IAP2 , and activate c-Jun NH ( 2 ) -terminal kinases
Imanishi et al., Clin Exp Pharmacol Physiol 2003
:
Inhibition of
NF-kappaB activation by SN50
suppressed c-IAP1 protein expression and enhanced apoptosis induced by either TNF-alpha or CH11
Wen et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
Consistent with this, we found that TL1A significantly increased the production of
c-IAP2 , a known NF-kappaB dependent anti-apoptotic protein, and that the
NF-kappaB inhibitor or cycloheximide
prevented its synthesis
Nawata et al., Oncogene 2003
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Expression of MEKK1km also reduced
NF-kappaB activation, and
inhibited antiapoptotic
c-IAP1 and c-IAP2 mRNA expression in response to the genotoxin
Misra et al., Circulation 2003
(Myocardial Infarction...) :
These studies suggest that the cytoprotective effects of
NF-kappaB are
mediated , at least in part, by Bcl-2 or
c-IAP1
Hübinger et al., Exp Hematol 2004
(Lymphoma, Large B-Cell, Diffuse) :
Furthermore, we showed that CD30 regulated expression of
cIAP1 and cIAP2 was
mediated by
NFkappaB
Kempf et al., Cell Microbiol 2005
:
The anti-apoptotic effect of B. henselae was accompanied by ( i ) the
activation of the transcription factor
NF-kappaB and ( ii ) the induction of cellular inhibitor of apoptosis proteins-1 and -2 (
cIAP-1 , -2 )
Fan et al., Oncogene 2005
:
HGF/SF induced the expression of several known NF-kappaB target genes (
cIAP-1 ( cellular inhibitor of apoptosis-1 ), cIAP-2, and TRAF-2 ( TNF receptor associated factor-2 ) ) in an
NF-kappaB dependent manner ; HGF/SF blocked the inhibition of expression of these genes by ADR
de Léséleuc et al., Cell Death Differ 2006
:
Nur77 overexpression leads to
NF-kappaB dependent induction of the antiapoptotic gene
cIAP1
Samuel et al., J Biol Chem 2006
:
Because TRAF2 regulates NF-kappaB activation, the
effects of
cIAP1 on TRAF2 mediated induction of
NF-kappaB transcriptional activity were studied using reporter gene assays
Groesdonk et al., Infect Immun 2006
:
This is associated with reduced expression of
NF-kappaB dependent antiapoptotic
c-IAP-2 and a loss of the mitochondrial transmembrane potential
Santoro et al., Nat Genet 2007
:
Using genetic and molecular approaches, we show that
Birc2 positively regulates the formation of the TNF receptor complex I in endothelial cells, thereby
promoting NF-kappaB activation and maintaining vessel integrity and stabilization
Kim et al., Cancer Lett 2008
:
In addition, treatment of PTX-2 down-regulated
NF-kappaB dependent gene expression, Cox-2, IAP-1,
IAP-2 and XIAP, at the transcriptional and translational level
Varfolomeev et al., J Biol Chem 2008
:
Here we investigate the
role of
c-IAP1 and c-IAP2 in TNFalpha stimulated activation of
NF-kappaB ... Therefore,
c-IAP1 and c-IAP2 are
required for TNFalpha stimulated RIP1 ubiquitination and
NF-kappaB activation
Mahoney et al., Proc Natl Acad Sci U S A 2008
:
Both
cIAP1 and cIAP2
regulate TNFalpha mediated
NF-kappaB activation ... Collectively, these data demonstrate that either
cIAP1 or 2 is
required for proper Rip1 polyubiquitination and
NF-kappaB activation upon TNFalpha treatment
Greene et al., Eur Respir J 2010
(Emphysema...) :
In 16HBE14o- cells but not HEK293 cells, ZAAT upregulated expression of
cIAP-1 , an upstream
regulator of
NF-kappaB
Fingas et al., Hepatology 2010
(Bile Duct Neoplasms...) :
Because
cIAP-1 and cIAP-2 also
promote nuclear factor kappa B (NF-kappaB) activation by the canonical pathway, the effect of JP1584 on this signaling pathway was examined