Gene interactions and pathways from curated databases and text-mining

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BIRC2 — RELA

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Uzzo et al., Clin Cancer Res 2002 (Prostatic Neoplasms) : In this study, we demonstrate by immunoblotting and immunohistochemistry that physiological levels of zinc inhibit activation of nuclear factor (NF)-kappa B transcription factor in PC-3 and DU-145 human prostate cancer cells, reduce expression of NF-kappa B-controlled antiapoptotic protein c-IAP2 , and activate c-Jun NH ( 2 ) -terminal kinases
Imanishi et al., Clin Exp Pharmacol Physiol 2003 : Inhibition of NF-kappaB activation by SN50 suppressed c-IAP1 protein expression and enhanced apoptosis induced by either TNF-alpha or CH11
Wen et al., J Biol Chem 2003 (MAP Kinase Signaling System) : Consistent with this, we found that TL1A significantly increased the production of c-IAP2 , a known NF-kappaB dependent anti-apoptotic protein, and that the NF-kappaB inhibitor or cycloheximide prevented its synthesis
Nawata et al., Oncogene 2003 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Expression of MEKK1km also reduced NF-kappaB activation, and inhibited antiapoptotic c-IAP1 and c-IAP2 mRNA expression in response to the genotoxin
Misra et al., Circulation 2003 (Myocardial Infarction...) : These studies suggest that the cytoprotective effects of NF-kappaB are mediated , at least in part, by Bcl-2 or c-IAP1
Hübinger et al., Exp Hematol 2004 (Lymphoma, Large B-Cell, Diffuse) : Furthermore, we showed that CD30 regulated expression of cIAP1 and cIAP2 was mediated by NFkappaB
Kempf et al., Cell Microbiol 2005 : The anti-apoptotic effect of B. henselae was accompanied by ( i ) the activation of the transcription factor NF-kappaB and ( ii ) the induction of cellular inhibitor of apoptosis proteins-1 and -2 ( cIAP-1 , -2 )
Fan et al., Oncogene 2005 : HGF/SF induced the expression of several known NF-kappaB target genes ( cIAP-1 ( cellular inhibitor of apoptosis-1 ), cIAP-2, and TRAF-2 ( TNF receptor associated factor-2 ) ) in an NF-kappaB dependent manner ; HGF/SF blocked the inhibition of expression of these genes by ADR
de Léséleuc et al., Cell Death Differ 2006 : Nur77 overexpression leads to NF-kappaB dependent induction of the antiapoptotic gene cIAP1
Samuel et al., J Biol Chem 2006 : Because TRAF2 regulates NF-kappaB activation, the effects of cIAP1 on TRAF2 mediated induction of NF-kappaB transcriptional activity were studied using reporter gene assays
Groesdonk et al., Infect Immun 2006 : This is associated with reduced expression of NF-kappaB dependent antiapoptotic c-IAP-2 and a loss of the mitochondrial transmembrane potential
Santoro et al., Nat Genet 2007 : Using genetic and molecular approaches, we show that Birc2 positively regulates the formation of the TNF receptor complex I in endothelial cells, thereby promoting NF-kappaB activation and maintaining vessel integrity and stabilization
Kim et al., Cancer Lett 2008 : In addition, treatment of PTX-2 down-regulated NF-kappaB dependent gene expression, Cox-2, IAP-1, IAP-2 and XIAP, at the transcriptional and translational level
Varfolomeev et al., J Biol Chem 2008 : Here we investigate the role of c-IAP1 and c-IAP2 in TNFalpha stimulated activation of NF-kappaB ... Therefore, c-IAP1 and c-IAP2 are required for TNFalpha stimulated RIP1 ubiquitination and NF-kappaB activation
Mahoney et al., Proc Natl Acad Sci U S A 2008 : Both cIAP1 and cIAP2 regulate TNFalpha mediated NF-kappaB activation ... Collectively, these data demonstrate that either cIAP1 or 2 is required for proper Rip1 polyubiquitination and NF-kappaB activation upon TNFalpha treatment
Greene et al., Eur Respir J 2010 (Emphysema...) : In 16HBE14o- cells but not HEK293 cells, ZAAT upregulated expression of cIAP-1 , an upstream regulator of NF-kappaB
Fingas et al., Hepatology 2010 (Bile Duct Neoplasms...) : Because cIAP-1 and cIAP-2 also promote nuclear factor kappa B (NF-kappaB) activation by the canonical pathway, the effect of JP1584 on this signaling pathway was examined