Gene interactions and pathways from curated databases and text-mining

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BMP15 — CDKN1A

Text-mined interactions from Literome

Carlberg et al., Differentiation 2001 : Infection of C3HIOT1/2 cells with this retroviral construct resulted in an infection efficiency of 90-95 % and was highly effective in converting cells in micromass culture to a chondrocyte phenotype, as assessed by positive Alcian blue staining for extracellular matrix proteoglycans, increased sulfate incorporation, increased expression of the cartilage marker genes collagen type II and aggrecan, and decreased expression of collagen type I. Interestingly, BMP-2 expression in the micromass cultures also induced the expression of the cell cycle inhibitory protein/differentiation factor p21/WAF1 , suggesting its functional involvement in chondrogenesis
Pouliot et al., J Endocrinol 2002 (Breast Neoplasms) : Role of Smad1 and Smad4 proteins in the induction of p21WAF1,Cip1 during bone morphogenetic protein induced growth arrest in human breast cancer cells ... Taken together, these results indicate that the mechanism of BMP induced p21 promoter activation involves BMP receptors and BMP Smads
Tomari et al., Int J Mol Med 2005 (Prostatic Neoplasms) : Furthermore, BMP-2 induced expression of p21 ( WAF1/CIP1 ), a CDK inhibitor
Pardali et al., J Cell Physiol 2005 : Signaling studies with all type I receptors of the TGF-beta superfamily show that BMP receptors induce higher p21 expression than TGF-beta/activin receptors ... Based on the previously known ability of c-Myc to block p21 expression and epithelial growth arrest in response to TGF-beta1, we demonstrate that ectopic c-Myc expression can abrogate Smad mediated p21 induction by all TGF-beta and BMP receptors
Yin et al., J Virol 2010 : Further, miR-155 inhibits SMAD1 and SMAD5 expression in the lung epithelial cell line A549, it inhibits BMP mediated induction of the cyclin dependent kinase inhibitor p21 , and it reverses BMP mediated cell growth inhibition
Jernvall et al., Development 1998 : The life history of an embryonic signaling center : BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot