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CA2 — NOS2

Text-mined interactions from Literome

Schaeffer et al., Diabetologia 1999 (Calcium Signaling...) : Inhibition of nitric oxide synthase by N-nitro-L-arginine ( L-NA ) augmented thapsigargin induced Ca2+ signalling by 51 % ( n = 8 )
Facchinetti et al., Neuroscience 1999 (Amyotrophic Lateral Sclerosis) : Levels of neuronal nitric oxide synthase as well as Ca2+ dependent nitric oxide synthase catalytic activity in the copper/zinc superoxide dismutase type 1 mutant mice do not differ from wild type mice
Palumbo et al., J Neurochem 1999 : Chemical, biochemical, and immunohistochemical evidence is reported demonstrating the presence in the brain of the cuttlefish Sepia officinalis of a Ca2+ dependent nitric oxide synthase , NMDAR2/3 receptor subunits, and glutamate, occurring in neurons and fibers functionally related to the inking system
Reyes-Harde et al., J Neurophysiol 1999 : Long-term depression ( LTD ) of synaptic transmission can be induced by several mechanisms, one thought to involve Ca2+ dependent activation of postsynaptic nitric oxide ( NO ) synthase and subsequent diffusion of NO to the presynaptic terminal
Chakrabarti et al., Biol Psychiatry 2000 : Rise of intrasynaptosomal Ca2+ level and activation of nitric oxide synthase in adult rat cerebral cortex pretreated with 3-5-3'-L-triiodothyronine
Asoh et al., Pediatr Res 2000 : Effect of antenatal dexamethasone treatment on Ca2+ dependent nitric oxide synthase activity in rat lung ... Ca2+ dependent nitric oxide synthase activity and nitrate/nitrite and cGMP concentrations in lungs of dexamethasone treated neonates, both premature and full-term, were significantly higher than those in the lungs of the control rats ... Ca2+ dependent nitric oxide synthase activity, nitrate/nitrite concentration, and cGMP concentration in the lungs of control rats showed developmentally associated increases during late gestation and in the early postnatal period
Kiemer et al., Immunol Cell Biol 2001 : The Ca2+-ionophore 4-Br-A23187 and thapsigargin, a compound known to liberate Ca2+ from intracellular stores, were further demonstrated to reduce LPS induced NO production in macrophages ( Griess assay ), confirming a functional link for elevated [ Ca2+ ] i and iNOS inhibition
Orihara et al., Nihon Hoigaku Zasshi 2000 (Brain Injuries...) : But, it is induced by inflammatory cytokines and the activity of iNOS is independent of elevated Ca2+
Song et al., Biochem J 2001 : Heat-shock protein 90 augments neuronal nitric oxide synthase activity by enhancing Ca2+/calmodulin binding
Mitamura et al., Eur J Pharmacol 2002 : These findings suggest that mesaconitine induced Ca2+ influx and activation of nitric-oxide synthase in endothelial cells and, thus, induced vasorelaxation in rat aorta
Masuda et al., J Urol 2002 : SDMA dependently inhibited Ca2+ dependent nitric oxide synthase activity in all regions, and electrical field stimulation induced relaxation in the trigone and proximal urethra
Sakai et al., Comp Biochem Physiol B Biochem Mol Biol 2002 : In the lysate of rabbit submandibular gland cells, Ca2+ regulated nitric oxide synthase activity was detected
Richter et al., Restor Neurol Neurosci 1998 : Tumor necrosis factor-a induces oxygen radicals in mitochondria through ceramides, and the recently discovered mitochondrial nitric oxide synthase profoundly stimulates Ca2+ release from mitochondria through formation of nitrogen monoxide and peroxynitrite
Klatt et al., J Biol Chem 1992 : Ca2+/calmodulin dependent cytochrome c reductase activity of brain nitric oxide synthase
Oguchi et al., FEBS Lett 1992 : Ca2+/calmodulin dependent nitric oxide synthase was found to be induced during rat liver necrosis caused by administration of Propionibacterium acnes and E. coli lipopolysaccharide to rats
Nakahata et al., Anesthesiology 2003 (Hypercapnia) : However, the selective Ca2+ dependent K+ channel antagonist iberiotoxin ( 10 ( -7 ) m ) as well as the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester ( 10 ( -4 ) m ) did not alter vasodilation
Yan et al., Neurosci Lett 2004 (Brain Ischemia) : Postsynaptic density protein 95 mediates Ca2+/calmodulin dependent protein kinase II-activated serine phosphorylation of neuronal nitric oxide synthase during brain ischemia in rat hippocampus
Azenabor et al., Biochem Cell Biol 2004 (Calcium Signaling) : Expression of iNOS gene in macrophages stimulated with 17beta-estradiol is regulated by free intracellular Ca2+
Yamamoto et al., J Comp Physiol B 2004 : Ca2+ , calmodulin and phospholipids regulate nitricoxide synthase activity in the rabbit submandibular gland
Tyagi et al., J Cell Biochem 2005 (Hyperhomocysteinemia...) : In this process, Ca2+ dependent mitochondrial nitric oxide synthase ( mtNOS ) and calpain are induced which lead to cytoskeletal de-arrangement and cellular remodeling
Roh et al., Am J Physiol Lung Cell Mol Physiol 2006 : The effects of KATP+ channel inhibition ( glybenclamide ), cyclooxygenase inhibition ( indomethacin ), nitric oxide synthase inhibition ( L-NAME ), and L-type voltage gated Ca2+ channel inhibition ( nifedipine ) on vasorelaxation responses to levcromakalim ( KATP+ channel activator ) alone and in combination with the anesthetics were assessed
Nakane et al., Biochem Biophys Res Commun 1991 : These findings indicate that brain nitric oxide synthase activity may be regulated not only by Ca2+/calmodulin and several co-factors, but also by phosphorylation
Xiao et al., J Proteome Res 2007 : The effect of Ca2+ on the interaction between iNOS and CaM has been examined as well
Azenabor et al., Immunobiology 2009 (Calcium Signaling) : Free intracellular Ca2+ regulates bacterial lipopolysaccharide induction of iNOS in human macrophages
Suzuki et al., Biochim Biophys Acta 2010 (Calcium Signaling) : Endothelial nitric oxide synthase is essential for nitric oxide generation, L-type Ca2+ channel activation and survival in RBL-2H3 mast cells
Stevens-Truss et al., Biochemistry 1995 : These results demonstrate that the binding interaction between CaM and iNOS is tight but reversible, requires Ca2+ , and is atypical from other known CaM -- enzyme interactions
Hecker et al., J Neurochem 1994 : In contrast to the predominantly particulate, Ca2+/calmodulin dependent nitric oxide ( NO ) synthase in endothelial cells, the corresponding neuronal isoenzyme is considered to be mainly soluble, presumably owing to the lack of a posttranslational myristoylation
Hecker et al., Biochem J 1994 : Endothelial cells ( EC ) contain a constitutive Ca2+/calmodulin dependent nitric oxide ( NO ) synthase ( cNOS ) which plays an important role in the local control of vascular tone
Davda et al., Eur J Pharmacol 1994 : These studies indicate that protein kinase C modulates the activity of the constitutive Ca2+/calmodulin dependent endothelial nitric oxide synthase in the basal state and following agonist stimulation through direct inhibition of the enzyme as well as receptor desensitization
Dokita et al., Eur J Pharmacol 1994 : Both soluble and particulate nitric oxide synthase activities were NADPH dependent, and the soluble activity was Ca2+ dependent
Koch et al., EMBO J 1994 (Synaptic Transmission) : Functional coupling of a Ca2+/calmodulin dependent nitric oxide synthase and a soluble guanylyl cyclase in vertebrate photoreceptor cells
Nagafuji et al., Acta Neurochir Suppl (Wien) 1994 (Brain Damage, Chronic...) : Temporal profiles of Ca2+/calmodulin dependent and -independent nitric oxide synthase activity in the rat brain microvessels following cerebral ischemia
Müller et al., Eur J Neurosci 1994 (Vision, Ocular) : Ca2+/calmodulin dependent nitric oxide synthase in Apis mellifera and Drosophila melanogaster
Regulski et al., Proc Natl Acad Sci U S A 1995 : Molecular and biochemical characterization of dNOS : a Drosophila Ca2+/calmodulin dependent nitric oxide synthase
Jordan et al., Surgery 1995 : Although iNOS is traditionally viewed as calcium independent, these data clearly show that [ Ca2+ ] i regulates iNOS messenger RNA induction and end product synthesis
Werner-Felmayer et al., Biochem J 1993 (Uterine Cervical Neoplasms) : Ca2+/calmodulin dependent nitric oxide synthase activity in the human cervix carcinoma cell line ME-180
Michel et al., Proc Natl Acad Sci U S A 1993 : In the vascular endothelium, diverse cell surface receptors are coupled to the Ca2+/calmodulin dependent activation of nitric oxide ( NO ) synthase
Dutrait et al., Neurosci Lett 1995 : This DMPO-OH production was abolished by EGTA, nitro-arginine and oxypurinol, suggesting that it was dependent on Ca2+ influx and subsequent activation of nitric oxide synthase and xanthine oxidase
Zoche et al., Biochemistry 1996 : The neuronal nitric oxide synthase and the macrophage nitric oxide synthase are differently regulated by Ca2+/calmodulin
Park et al., Immunology 1996 (Leukemia, Experimental) : Because the role of intracellular Ca2+ in the two-signal process for the induction of nitric oxide ( NO ) synthesis is controversial, this study was undertaken to examine the role of Ca2+ in the transcriptional regulation of inducible NO synthase (iNOS) in murine peritoneal macrophages ... To confirm that iNOS induction was due to the changes in the intracellular Ca2+ level, the acetoxymethyl ester of 1,2-bis ( 2-aminophenoxy ) ethane-N, N,N ', N'-tetraacetic acid ( BAPTA-AM ), an intracellular Ca2+ chelator, was used
Iranami et al., Anesthesiology 1996 : Halothane can inhibit the nitric oxide-cyclic GMP mechanism only when Ca2+ release is greatly involved in the activation of constitutive nitric oxide synthase
Bicker et al., Eur J Neurosci 1996 (Second Messenger Systems) : Nitric oxide is generated by a Ca2+/calmodulin stimulated nitric oxide synthase and activates soluble guanylyl cyclase
He et al., Am J Physiol 1997 : Effect of nitric oxide synthase inhibitors on endothelial [Ca2+ ] i and microvessel permeability
Wayte et al., Neuroreport 1996 : L-arginine uptake was reduced by L-ornithine ( 10 microM-1 mM ), high extracellular K+ ( 56 mM ), L-glutamate ( 100 microM ) and removal of extracellular Ca2+ , but was increased by the nitric oxide synthase inhibitor, Nw-nitro-L-arginine benzyl ester ( L-NABE ; 1 mM )
Colasanti et al., J Biol Chem 1997 (Astrocytoma) : Bacterial lipopolysaccharide plus interferon-gamma elicit a very fast inhibition of a Ca2+ dependent nitric-oxide synthase activity in human astrocytoma cells
Agulló et al., Eur J Pharmacol 1997 : Cyclic GMP ( cGMP ) formation induced by agonist stimulation of Ca2+/calmodulin dependent nitric oxide ( NO ) synthase type I is known to occur in both granule cell and astrocyte cultures from rat cerebellum
Smith et al., J Physiol 1997 : The neutral nitric oxide synthase inhibitors NG-nitro-L-arginine ( L-NNA ) and N omega-monomethyl-L-arginine ( L-NAME ) also increased [Ca2+ ] i. D-Arginine was ineffective
Michel et al., J Biol Chem 1997 : Reciprocal regulation of endothelial nitric-oxide synthase by Ca2+-calmodulin and caveolin
He et al., Am J Physiol 1997 : Effect of nitric oxide synthase inhibitors on basal microvessel permeability and endothelial cell [Ca2+ ] i
Mitsui et al., Arch Oral Biol 1997 : These findings suggest that the rabbit parotid glands are useful for studying the regulation of nitric oxide generation by Ca2+/calmodulin dependent nitric oxide synthase in salivary glands
Shirato et al., Biochem J 1998 : Molecular cloning and characterization of Ca2+ dependent inducible nitric oxide synthase from guinea-pig lung
Wang et al., Burns Incl Therm Inj 1998 (Burns...) : Cytosol from control group animals was shown to contain mainly Ca2+ dependent nitric oxide synthase ( cNOS ) with a small amount of Ca2+ independent nitric oxide synthase (iNOS)
Paltauf-Doburzynska et al., J Physiol 1998 : Stealth ryanodine-sensitive Ca2+ release contributes to activity of capacitative Ca2+ entry and nitric oxide synthase in bovine endothelial cells
Feron et al., Curr Opin Nephrol Hypertens 1999 : Nitric oxide production by the Ca2+/calmodulin dependent enzyme endothelial nitric oxide synthase primarily reflects changes in intracellular [Ca2+ ], increasing as Ca2+ rises and decreasing as Ca2+ falls ... This simplistic bimodal mechanism of regulation has recently been refined by the finding that the binding of Ca2+/calmodulin to endothelial nitric oxide synthase involves the disruption of the association of endothelial nitric oxide synthase from the scaffolding protein caveolin and the subsequent translocation of the enzyme from plasmalemmal caveolae