Gene interactions and pathways from curated databases and text-mining

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CASP3 — CASP9

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Sun et al., Oncogene 1999 (Adenocarcinoma...) : The caspase inhibitors ( Z-DEVD-FMK and Z-VAD-FMK ) suppressed CD437 induced CPP32-like caspase activation and apoptosis in both cell lines
Selznick et al., J Neuropathol Exp Neurol 2000 : Caspase-3 deficiency, or pharmacological inhibition of caspase activity, prevented caspase-3 activation and blocked the appearance of apoptotic nuclear features but not Abeta induced neuronal death
Nakatsuka et al., Neurosci Lett 2000 (Ischemic Attack, Transient) : Although pro-caspase-3 was strongly detected, active caspase-3 was not detected before and until 84 h after 5-min ischemia
De Saint Jean et al., Invest Ophthalmol Vis Sci 2000 : Apoptosis was confirmed by a cleavage of PARP and CPP32 , by caspase-8 activation , and by an index Hoechst/neutral red greater than one
Robertson et al., Crit Rev Toxicol 2000 : Caspase-9 can signal downstream and activate pro-caspase-3 and -7
Zhang et al., J Neurosci 2000 (Alzheimer Disease) : Caspase-3 induces neuronal apoptosis in 20 % of the cells, whereas caspase-7 or -8 do not induce apoptosis
Tomicic et al., Biochem Biophys Res Commun 2001 : Caspase-3- and caspase-9 mediated cleavage of Bcl-2 was efficiently blocked by caspase-3 ( zDEVD ) and caspase-9 ( zLEHD ) inhibitor, respectively
Kagawa et al., Clin Cancer Res 2001 : Caspase-3 deficiency, however, did not affect Bax induced levels of poly ( ADP-ribose ) polymerase cleavage, caspase-6 activation, and lamin B cleavage
Kumi-Diaka et al., Biol Cell 2000 (Carcinoma...) : The major findings of these studies are : i ) genistein inhibits growth and proliferation of both LNCaP and DU145 cells via apoptosis mainly, and necrosis at higher concentrations ; ii ) genistein induces activation and expression of caspase-3 ( CPP32 ) in both target cells ; iii ) genistein induced apoptosis and CPP32 activation could be significantly inhibited by the caspase-3 inhibitor, z-VAD-fmk ( N-benzyloxycarbonyl-Val-Asp-fluoromethyl-ketone ), thus confirming a mediator role of CPP32 in the genistein induced apoptotic pathway in the target cells
Stadelman et al., Brain Pathol 2001 (Fetal Death...) : Expression of apoptosis associated proteins p53, bcl-2, bax, and caspase-3/CPP32 , activation of caspase-3 , and modification of proteins via poly ( ADP-ribosyl ) ation was studied in pontosubicular neuron necrosis ( PSN ), a form of perinatal brain damage revealing the morphological hallmarks of neuronal apoptosis
Viswanath et al., J Neurosci 2001 (Disease Models, Animal...) : Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson 's disease ... Caspase-9 inhibition prevented the activation of both caspase-3 and caspase-8 and also inhibited Bid cleavage, but not cytochrome c release
Kwon et al., Exp Mol Med 2002 : Caspase-3 selective inhibitor, Ac-DEVD-CHO, prevented both the activation of caspase-3 and cleavage of poly ( ADP-ribose ) polymerase ( PARP )
Robertson et al., Toxicology 2002 (Necrosis) : Caspase-9 can signal downstream and activate pro-caspase-3 and -7
Chandra et al., J Biol Chem 2003 : Here we present evidence that the mitochondrially localized active caspase-9 and -3 result mostly from translocation from the cytosol ( into the intermembrane space ) and partly from caspase mediated activation in the organelle rather than from the Apaf-1 mediated activation
Xu et al., Anticancer Res 2003 (Pancreatic Neoplasms) : Caspase-8 and -3 activities were increased by TRAIL treatment and apoptosis was largely blocked by caspase-8 and -3 inhibitors
Schoemaker et al., J Hepatol 2003 (Cholestasis...) : Apoptosis was determined by TUNEL staining, active caspase-3 staining, activation of caspase-8 , -9 and -3
Aouad et al., J Immunol 2004 : Caspase-3 is a component of Fas death inducing signaling complex in lipid rafts and its activity is required for complete caspase-8 activation during Fas mediated cell death
Cuello et al., Cell Death Differ 2004 : Caspase-9 may further activate caspase-8 , generating an amplification loop
Yang et al., Nephron. Experimental nephrology 2004 (Necrosis) : Here we evaluate three caspase inhibitors : B-D-FMK ( pan caspase inhibitor ), Z-DEVDFMK ( predominantly Caspase-3 inhibitor ) and Z-VAD-FMK ( predominantly Caspase-1 and -3 inhibitor ) to ameliorate apoptosis induced by cisplatin in rat proximal tubular ( RPT ) cells
Kusunoki et al., BMC pharmacology 2004 (Arthritis, Rheumatoid) : Caspase-3 activity was increased by treatment with triptolide and was suppressed by caspase inhibitors
Martin et al., J Biol Chem 2005 : Caspase-9 cleaves and activates effector caspases, predominantly caspase-3 , resulting in the demise of the cell
Lang-Rollin et al., Apoptosis 2005 : Caspase 9 and 3 are processed, cytochrome c is released from the mitochondria and a dominant negative form of caspase 9 prevents death
Liszewska et al., Prostaglandins Other Lipid Mediat 2005 : Treatment of luteal cells with P4 and PGE2 for 24 h decreased ( P < 0.05 ) level of active caspase-3 while aminoglutethimide ( P < 0.05 ), spermine NONOate ( P < 0.05 ), and staurosporine ( P < 0.001 ) increased caspase-3 activity in the cells
Daher et al., Exp Dermatol 2006 : Caspase-9-DN and zLEHD-fmk both suppressed caspase-9 , -3, and -8 activity after UVB exposure, as well as proteolytic processing of procaspase-3 into its active form, DNA fragmentation factor 45 cleavage, and internucleosomal DNA fragmentation
Shankar et al., J Neurosci 2006 : Rhgas6 and caspase inhibitors also reduced active caspase-3 immunoreactivity relative to TNFalpha-only treated cultures
Nakadai et al., Toxicology 2006 : Chlorpyrifos also induced an increase of intracellular active caspase-3 in U937 cells in a dose dependent manner, and a caspase-3 inhibitor, Z-DEVD-FMK, significantly inhibited the chlorpyrifos induced apoptosis
Legewie et al., PLoS Comput Biol 2006 : We demonstrate that this positive feedback brings about bistability ( i.e., all-or-none behaviour ), and that it cooperates with Casp3 mediated feedback cleavage of Casp9 to generate irreversibility in caspase activation
Yang et al., Apoptosis 2006 : Caspase-3 mediated-feedback and activation of caspase-8 and -9 in MCF-7/C3 cells is further supported by an increase in the cleavage of caspase-8 and 9 substrates and cytochrome c release
Koo et al., Am J Chin Med 2007 : Caspase-3 activation and subsequent apoptotic cell death in MGG treated cells were partially blocked by the caspase-3 inhibitor, Z-DEVD-FMK
Ikeda et al., Exp Cell Res 2007 : Caspase-3 activation is also induced, but the caspase inhibitor, Z-VAD-FMK, does not block RASSF6 mediated apoptosis
Wong et al., Biochim Biophys Acta 2007 : Caspase-3 is activated by cleavage of caspase-8 and caspase-9
Uchiyama et al., Infect Immun 2007 (Necrosis) : Caspase-9 activation was also detected in H37Rv infected cells, but H37Ra never induced such caspase-9 activation
Denault et al., Biochem J 2007 : Caspase 3 attenuates XIAP ( X-linked inhibitor of apoptosis protein ) -mediated inhibition of caspase 9
Feng et al., J Huazhong Univ Sci Technolog Med Sci 2007 : Caspase-3 inhibitors can suppress caspase-3 activity and reduce the apoptosis rate significantly
Ruiz-Vela et al., FEBS Lett 2007 : Cytochrome c (CYT c) is a protein that employs the caspase recruitment domain ( CARD ) -containing proteins APAF-1 and CASP-9 to activate effectors CASP-3 and -7
Li et al., Toxicology 2007 : DDVP also induced an increase of intracellular active caspase-3 in NK-92CI in a dose- and time dependent manner, and a caspase-3 inhibitor, Z-DEVD-FMK, significantly inhibited DDVP induced apoptosis, suggesting that this apoptosis is partially mediated by activation of intracellular caspase-3
Wei et al., Zhonghua Xue Ye Xue Za Zhi 2007 : The caspase-3 activity was markedly enhanced, and the active caspase-3 in K562/ADM cells increased by about 40 % compared to liposome alone and non silencing controls
Audo et al., Arthritis Res Ther 2007 (Arthritis, Rheumatoid) : Caspase 3 , a key mediator of apoptosis, was not activated in celecoxib treated RA FLSs, and the presence of specific caspase 3 or pan-caspase inhibitors did not affect celecoxib induced cell death
Scarlatti et al., Cell Death Differ 2008 (Breast Neoplasms) : Here we show that resveratrol arrests cell proliferation, triggers death and decreases the number of colonies of cells that are sensitive to caspase-3 dependent apoptosis ( MCF-7 casp-3 ) and also those that are unresponsive to it ( MCF-7vc )
Li et al., Toxicology 2009 : Chlorpyrifos also induced an increase in intracellular active caspase-3 in Jurkat T cells in a dose- and time dependent manner, and a caspase-3 inhibitor, Z-DEVD-FMK, significantly inhibited chlorpyrifos induced apoptosis
Zhao et al., Tohoku J Exp Med 2008 (Myocardial Infarction...) : Caspase-9 cleaves and activates caspase-3
Liang et al., Zhonghua Yu Fang Yi Xue Za Zhi 2008 : p, p'-DDE, beta-BHC and their mixture could induce the apoptosis of Sertoli cells in vitro which was associated with activation of Caspase-3 mediated by cleavage of Caspase-8 and Caspase-9
Tang et al., Oncol Rep 2009 (Adenocarcinoma...) : Caspase-9 and -3 inhibitors almost completely suppressed HCT induced caspase-9 and -3 activities ... Caspase-9 and -3 inhibitors almost completely suppressed HCT induced caspase-9 and -3 activities
Shi et al., Toxicol Lett 2010 : Caspase 9 inhibition blocked the TNP induced activation of caspase 3 significantly
Ohsawa et al., Proc Natl Acad Sci U S A 2010 : Maturation of the olfactory sensory neurons by Apaf-1/caspase-9 mediated caspase activity ... Here, we provide unique evidence that Apaf-1/caspase-9 mediated caspase signaling regulates the development of olfactory sensory neurons ( OSNs ), which includes axonal projection, synapse formation, and maturation of these neurons
Li et al., Arch Toxicol 2011 (Necrosis) : DNA fragmentation was detected when cells were treated with 0.5, 1, or 2 µM ziram for 24 h. Ziram also induced an increase in intracellular active caspase-3 in U937 cells in a dose dependent manner, and a caspase-3 inhibitor, Z-DEVD-FMK, significantly inhibited the ziram induced apoptosis
Xiao et al., Apoptosis 2011 : Caspase-3 activity was 10-fold higher in myotubes compared to myoblasts, and Stsp caused a significant caspase-3 induction in both
Jeyasuria et al., Biol Reprod 2011 : The IAP family members are the only endogenous inhibitors of active caspase 3 , and MCL1 limits activation of caspase 3 by suppressing proapoptotic signaling
Aras et al., Brain Res 2012 (Gliosis) : Reactive neonatal and adult astrocytes demonstrated an increase in total caspase activity with a corresponding increase in the expression of active caspase-3 in the absence of cell death
Edgington et al., Chem Biol 2012 : We also demonstrate that caspase-6 activation does not require active caspase-3/-7 , suggesting that it may autoactivate or be cleaved by other proteases
Nelson et al., Crit Care Med 2012 (Muscular Atrophy) : These findings support our hypothesis that a regulatory calpain/caspase-3 cross-talk exists whereby calpain can promote caspase-3 activation and active caspase-3 can enhance calpain activity in diaphragm muscle during prolonged mechanical ventilation
Wang et al., PloS one 2012 : Caspase assay demonstrated that Caspase-3, -8, -9 enzyme activities in newt testis were significantly elevated after heat shock ( 40°C 2 h ), cold exposure ( 4°C 12 h ), and cadmium exposure ( Cd 36 h ), while Caspase3 and Caspase8 activities were increased with Caspase9 significantly decreased after starvation treatment
Chan et al., J Virol 2012 : However, HCMV infection does induce a temporal activation of caspase 3, with only a low level of active caspase 3 being observed after the 48-h viability checkpoint
Liu et al., PloS one 2012 : Caspase-9 inhibitor could inhibit activation of pro-caspase-3 , and the inhibition of the function of Apaf-1 with FSBA blocked apoptosis, hinting that Apaf-1 could be involved in Sl-1 cell apoptosis induced by AfMNPV
Jiang et al., Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 2013 : Subchronic exposure to B [ a ] P can induce apoptosis of hippocampal neurons ; its mechanism may be related to the fact that B [ a ] P can induce upregulated expression of Bax, inhibit expression of Bcl-2, lead to decrease in Bcl-2/Bax ratio, induce upregulated expression of Caspase-3 and Caspase-6, and cause increase in the activities of Caspase-3, Caspase-6, and Caspase-9
Wu et al., Food Chem Toxicol 2013 : Caspase-3 inhibitor also efficiently blocked CD95 ( APO-1/CD95 ) and Bax expression, caspase-3 activation and PARP cleavage, whereas antioxidant N-acetyl-l-cysteine, AMPK inhibitor and AMPK siRNA effectively blocked the AMPK phosphorylation
Wright et al., J Exp Med 1997 (Lymphoma) : Only the caspase inhibitors, however, prevented activation of CPP32-like activity as revealed by cleavage of the synthetic substrate, DEVD-pNa, by cell cytosols, and also by in vivo cleavage of poly ( ADP-ribosyl ) polymerase, a known substrate of CPP32
Deveraux et al., EMBO J 1998 : In contrast, these IAP family proteins did not prevent caspase-8 induced proteolytic activation of pro-caspase-3 ; however, they subsequently inhibited active caspase-3 directly, thus blocking downstream apoptotic events such as further activation of caspases
Cecconi et al., Cell 1998 (Craniofacial Abnormalities...) : The cytosolic protein APAF1, human homolog of C. elegans CED-4, participates in the CASPASE 9 (CASP9) dependent activation of CASP3 in the general apoptotic pathway