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CD40 — IL6
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
von Leoprechting et al., Cancer Res 1999
(Melanoma) :
CD40 ligation on MM by CD40L transfected murine L-cells or by a soluble CD40L fusion protein
up-regulated their expression of intercellular adhesion molecule-1 and MHC class I and class II molecules and their secretion of
IL-6 , IL-8, tumor necrosis factor-a, and granulocyte macrophage colony stimulating factor and also induced a rapid activation of the transcription factor nuclear factor kappaB
Bartholomé et al., J Interferon Cytokine Res 1999
:
IFN-beta interferes with the differentiation of dendritic cells from peripheral blood mononuclear cells : selective inhibition of
CD40 dependent
interleukin-12 secretion
Kitagawa et al., Arthritis Rheum 1999
(Arthritis, Rheumatoid) :
Differential
regulation of rheumatoid synovial cell
interleukin-12 production by tumor necrosis factor alpha and
CD40 signals
Anderson et al., Semin Oncol 1999
(Herpesviridae Infections...) :
CD40 activation of myeloma cells changes their cell surface phenotype,
triggers autocrine
interleukin-6 secretion, and can regulate myeloma cell cycle in a p53 dependent fashion
Manzel et al., J Leukoc Biol 1999
:
Both CpG-ODN and engagement of
CD40 protects WEHI-231 murine B lymphoma cells from apoptosis induced by antibody to surface IgM, and both agents
induce interleukin-6 (IL-6) production by these cells
Muraille et al., Blood 1999
:
Anti-CD3epsilon treatment was found to induce a selective deficiency in the ability of spleen cells to produce bioactive
interleukin-12 in
response to
CD40 stimulation
Baccam et al., Eur J Immunol 1999
:
In this study, we characterize the specific molecular requirements for
CD40 mediated
IL-6 production ... Thus,
CD40 mediated
IL-6 induction is independent of NF-kappaB activation and the binding of TRAF2 and -3, but CD40 must be engaged by trimeric CD154 on cell membranes to activate production of IL-6
Jalukar et al., J Immunol 2000
:
Using both molecules, we found that TRAF6 association with CD40 is important for
CD40 induced
IL-6 and Ig secretion, and that TRAF6 mediates its effects on CD40 stimulated Ig secretion principally through its effects on IL-6 production by the B cell
Amo et al., J Dermatol Sci 2000
(Neoplasms, Basal Cell...) :
CD40 ligation inhibits trichilemmoma cell proliferation and
induces IL-6 production
Sugiura et al., J Immunol 2000
(Dermatomyositis...) :
Increased CD40 expression on muscle cells of polymyositis and dermatomyositis :
role of
CD40-CD40 ligand interaction in
IL-6 , IL-8, IL-15, and monocyte chemoattractant protein-1 production
Bergamini et al., J Infect Dis 2000
(HIV Infections) :
The effect of HIV-1 infection on recombinant
CD40 ligand (CD40L) induced interleukin (IL)-1beta and
IL-6 production by human macrophages was analyzed
Willermain et al., Invest Ophthalmol Vis Sci 2000
:
Although interferongamma enhanced
IL-6 and IL-8 production,
CD40 triggering of IFNgamma activated hRPE cells did not
induce IL-12 secretion
Koumas et al., Am J Pathol 2001
:
Engagement of
CD40 in the Thy 1 ( + ) subpopulation
induced IL-6 , IL-8, and MCP-1
Atamas et al., J Immunol 2002
:
In contrast, there was no evidence that synergy was
mediated by an increased expression of IL-4Ralpha chain,
CD40 , or the autocrine profibrotic cytokines
IL-6 and TGF-beta
Mann et al., J Biol Chem 2002
:
CD40 induces
interleukin-6 gene transcription in dendritic cells : regulation by TRAF2, AP-1, NF-kappa B, AND CBF1 ... Further promoter assays showed that the transcription factors NF-kappaB and AP-1 are downstream transcriptional mediators of
CD40 induced
IL-6 gene expression ... Overexpression of CBF1 resulted in a profound inhibition of basal and
anti-CD40 induced
IL-6 promoter activities indicating that prolonged induction of CBF1 may contribute to the transient nature of the IL-6 response
Companjen et al., Int Immunol 2002
:
In vitro studies have shown that
CD40 ligation on human keratinocytes
results in the production of
IL-6 and IL-8 as well ...
IL-6 , IL-8, tumor necrosis factor (TNF)-alpha, IL-12 and IL-1 beta were
induced upon CD40 ligation and IFN-gamma stimulation, while IL-10 could be induced by
CD40 ligation alone and was reduced again by the addition of IFN-gamma ... Since CD40 ligation on monocytes and dendritic cells in vitro results in the secretion of IL-1, which is pre stored in high concentrations in normal human keratinocytes, we subsequently investigated whether
CD40 induced
IL-6 and IL-8 production in skin is mediated via IL-1 ... Indeed IL-1 receptor antagonist inhibited the
CD40 ligation
induced IL-6 and IL-8 production, while TNF-alpha and IL-10 production were not affected ... These data show that
CD40 ligation
induced secretion of
IL-6 and IL-8, but not TNF-alpha and IL-10, is partially mediated via IL-1 and that IL-1 plays a prominent role in the inflammatory response initiated by CD40 ligation in intact human skin
Fu et al., Zhonghua Xue Ye Xue Za Zhi 2002
:
BMSC expressed
CD(40) and the production of
IL-6 and FL
increased after stimulated with 5C11 while IL-3 and SCF had no change
Dongari-Bagtzoglou et al., Inflamm Res 2003
:
CD40 ligation triggers COX-2 expression in endothelial cells : evidence that
CD40 mediated
IL-6 synthesis is COX-2 dependent
Cattaruzza et al., J Biol Chem 2003
:
Interleukin-10 induction of nitric-oxide synthase expression attenuates
CD40 mediated
interleukin-12 synthesis in human endothelial cells
Fukasawa et al., Eur J Immunol 2003
(Scleroderma, Systemic) :
Ligation of
CD40 by recombinant human CD154 ( 0.5-2 microg/ml )
resulted in increased production of
IL-6 , IL-8, and monocyte chemoattractant protein-1 in SSc fibroblasts in a dose dependent manner, whereas these phenomena were not shown in normal fibroblasts even with the addition of CD154
Lee et al., Mol Cell Biochem 2003
:
We previously demonstrated that ROS are generated by cross linking surface receptor
CD40 and consequently
induce c-Jun N-terminal kinase activation and
interleukin-6 secretion in murine B cells
Wagner et al., J Immunol 2004
:
Similar to CpG ODN,
CD40 ligand (CD40L) alone
induced IL-6 , TNF-alpha, and IL-10
Jeurissen et al., Eur J Immunol 2004
(Hypergammaglobulinemia) :
Furthermore, we showed that caps-PS induce production of IL-4,
IL-6 , IL-10, and IFN-gamma, and that this enhanced production was
inhibited by blocking the
CD40-CD40L interaction
Cao et al., Oral Oncol 2005
(Head and Neck Neoplasms...) :
CD40 ligation specifically
increased the secretion of IL-8, VEGF and PGE ( 2 ) but not
IL-6 , IL-10, FasL, GM-CSF, or TGFalpha
Scheffel et al., Inflamm Res 2005
:
ATRA interferes through several pathways with the
anti-CD40 plus IL-4 mediated B cell
activation , namely
IL-6 , CD23 and CD54
Pinzon-Charry et al., Neoplasia (New York, N.Y.) 2005
(Adenocarcinoma...) :
Importantly, despite DR ( + ) IC 's poor responsiveness to inflammatory factors, in samples from healthy volunteers and breast cancer patients,
CD40 ligation
induced phenotypic maturation and
interleukin 12 secretion, in turn generating more efficient T-cell responses
Yanagawa et al., Immunology 2006
:
Taken together, we concluded that
IL-6 and IL-12 productions in
response to
CD40 ligation were controlled by p38 MAPK and NIK mediated alternative pathway, respectively, in mature DCs
Clark et al., J Immunol 1990
:
The effect of
IL-6 on M12/CD40+ cells not only
required intact
CD40 including threonine 234 but also was specific because IL-6 mAb blocked the inhibitory activity ... Similar effects were evident in human CD40+ B cells :
IL-6 increased the phosphorylation of
CD40 in the IL-6-responsive cell line, CESS, and CD40 mAb induced IL-6 production in activated human B cells
Zhang et al., J Immunol 1991
:
Anti-CD23 and
anti-IL-6 also could not
block anti-CD40 plus IL-4 induced IgE production, but anti-IL-4 totally blocked their effect
D'Alimonte et al., J Immunol 2007
:
Culture pretreatment with guanosine ( 10-300 microM ), starting 1 h before cytokine or Abeta addition, dose-dependently
inhibited the CD40 induced expression as well as functional
CD40 signaling by suppressing
IL-6 production promoted by IFN-gamma/TNF-alpha challenge in the presence of CD40 cross linking
Danese et al., Gut 2007
(Colitis...) :
Engagement of
CD40 on HIFs
promoted the release of vascular endothelial growth factor ( VEGF ),
interleukin-8 (IL-8) and hepatocyte growth factor (HGF)
Ono et al., Immunology 2007
:
CD86 expression and
CD40 mediated
interleukin-6 production were completely diminished in GiDCs, which might be associated with the impaired ability of the GiDCs to induce Th2 differentiation
Bose et al., Hum Immunol 2007
(Carcinoma, Squamous Cell...) :
Natural killer cell mediated cytotoxicity of tumor cells initiated by neem leaf preparation is associated with
CD40-CD40L mediated endogenous production of
interleukin-12
Hillion et al., J Immunol 2007
:
Coordinated engagement of the BCR and
CD40 promoted the synthesis of
IL-6 and, thereby, up-regulation of its receptor on activated B lymphocytes
Wan et al., Arthritis Rheum 2008
(Disease Models, Animal...) :
Anti-CD40 treatment
induced a higher production of
interleukin-6 (IL-6) , soluble IL-6 receptor ( sIL-6R ), IL-10, and tumor necrosis factor alpha in B6.TC DCs
Rezai-Zadeh et al., Journal of neuroinflammation 2008
(Encephalitis) :
Apigenin and luteolin also suppressed microglial TNF-alpha and
IL-6 production stimulated by IFN-gamma challenge in the
presence of
CD40 ligation
Hwang et al., Invest Ophthalmol Vis Sci 2009
(Graves Ophthalmopathy) :
In the present study the authors investigated the
role of
CD40 ligation on macrophage chemoattractant protein-1 ( MCP-1 ),
IL-6 , and IL-8 expression in fibroblasts from patients with TAO
Perona-Wright et al., J Immunol 2009
(Encephalomyelitis, Autoimmune, Experimental) :
A pivotal role for
CD40 mediated
IL-6 production by dendritic cells during IL-17 induction in vivo ... Engagement of
CD40 on P. acnes conditioned DC
stimulated the release of IL-12, IL-23, and
IL-6 , of which IL-6 alone proved essential for Th17 differentiation
Lin et al., J Neurochem 2009
:
In granulocyte-macrophage colony stimulating factor ( GMCSF ) -induced dendritic cell-like microglia,
IL-6/sIL-6R and IFNgamma
stimulated an even greater increase in
CD40 expression compared with primary microglia
Fair et al., J Immunotoxicol 2011
(Body Weight) :
Ex vivo
IL-6 production by B-cells was significantly
increased by in vitro stimulation with either
anti-CD40 or lipopolysaccharide
Arcipowski et al., PloS one 2012
:
We determined that TAK1 was required for JNK activation and
interleukin-6 (IL-6) production
mediated by
CD40 and LMP1, in both mouse and human B cells
Wu et al., J Lipid Res 2012
(Hyperlipidemias) :
Abundance of miR-181a attenuated ox-LDL induced CD83 and
CD40 expression,
inhibited the secretion of
interleukin (IL)-6 and TNF-a, and up-regulated IL-10, an important anti-inflammatory cytokine that was inhibited by ox-LDL
Gruss et al., Blood 1994
(Hodgkin Disease...) :
We found that recombinant
CD40 ligand (CD40L) induced interleukin-8 (IL-8) secretion and
enhanced IL-6 , TNF, and lymphotoxin-alpha ( LT-alpha/TNF-beta ) release from cultured H-RS cells
Tong et al., Blood 1994
(Multiple Myeloma...) :
Ligand binding of the B-cell lineage antigen
CD40 enhances growth and
interleukin-6 (IL-6) secretion in human B cells ( the CD40/IL-6 loop )
Berberich et al., J Immunol 1994
:
Cross linking
CD40 on B cells can
lead to homotypic cell adhesion,
IL-6 production, and, in combination with cytokines, to Ig isotype switching
Yellin et al., J Leukoc Biol 1995
(Arthritis, Rheumatoid...) :
Ligation of
CD40 on fibroblasts
induces CD54 ( ICAM-1 ) and CD106 ( VCAM-1 ) up-regulation and
IL-6 production and proliferation
Hess et al., J Immunol 1995
:
Stimulation of the transformed fibroblast cell line SV80 with
CD40 ligand (CD40L) or anti-CD40 Ab
resulted in the production of
IL-6 ; this could be increased by IFN-gamma pretreatment, which is known to up-regulate CD40 expression ... Studies with transfectants overexpressing CD40 demonstrated that activation of
CD40 alone is
sufficient to induce
IL-6 production ... The transcription factor NF-kappa B appears to play a central role in
CD40 mediated activation of the
IL-6 gene ; NF-kappa B mobilization directly preceded CD40 mediated IL-6 production, and suppression of NF-kappa B mobilization with the metabolic inhibitor D609 also suppressed the IL-6 response
Kennedy et al., Eur J Immunol 1996
:
CD40/CD40 ligand interactions are
required for T cell dependent production of
interleukin-12 by mouse macrophages
Cella et al., J Exp Med 1996
:
Ligation of
CD40 on dendritic cells
triggers production of high levels of
interleukin-12 and enhances T cell stimulatory capacity : T-T help via APC activation
Tong et al., Leukemia & lymphoma 1996
(Multiple Myeloma) :
For normal B cells, the cross linking of
CD40 induces cell cycle progression, long-term proliferation in vitro, IgE secretion, increased adhesion molecule ( LFA-1 ) expression, and low level
IL-6 secretion
Sempowski et al., J Periodontol 1997
(Gingivitis...) :
This concept was further substantiated by the fact that
CD40 engagement
stimulated interleukin 6 (IL-6) production by gingival fibroblasts, but not periodontal ligament fibroblasts ... This
CD40/CD40L interaction can
stimulate fibroblast activation and synthesis of the proinflammatory cytokine
IL-6
Yoshimoto et al., Eur J Immunol 1997
:
Induction of
interleukin-12 p40 transcript by
CD40 ligation via activation of nuclear factor-kappaB
Teoh et al., J Clin Invest 1998
(Multiple Myeloma) :
Previous studies have shown that triggering multiple myeloma ( MM ) cells via
CD40 induces
IL-6 mediated autocrine growth as well as increased expression of cell surface adhesion molecules including CD11a, CD11b, CD11c, and CD18
Jeppson et al., J Immunol 1998
:
Furthermore, IL-4 and
anti-CD40 synergized for the production of
IL-6
Lazaar et al., J Immunol 1998
:
Cross linking
CD40 on ASM
resulted in enhanced
IL-6 secretion and an increase in intracellular calcium concentrations, which were dependent on calcium influx ... In addition, inhibition of calcium influx inhibited both
CD40 mediated NF-kappaB activation and
enhancement of
IL-6 secretion
Revy et al., Eur J Immunol 1998
(Immunologic Deficiency Syndromes) :
We show that the
CD40 induced production of
IL-6 , IL-8 and TNF-alpha by monocytes, and IL-12 by dendritic cells, and expression of the activation markers CD83, the costimulatory molecules CD86 and CD80, and HLA-DR antigens were all similar in patient and control cells
Séguin et al., J Infect Dis 1999
:
Sensitized lymphocytes and
CD40 ligation
augment interleukin-12 production by human dendritic cells in response to Toxoplasma gondii