Gene interactions and pathways from curated databases and text-mining

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BCR — CEBPA

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Perrotti et al., Nat Genet 2002 (Blast Crisis...) : BCR-ABL suppresses C/EBPalpha expression through inhibitory action of hnRNP E2 ... Our results indicate that BCR-ABL regulates the expression of C/EBPalpha by inducing hnRNP E2-which inhibits the translation of CEBPA mRNA
Schuster et al., Blood 2003 : The effects of Bcr-Abl on C/EBP transcription-factor regulation and neutrophilic differentiation are reversed by the Abl kinase inhibitor imatinib mesylate ... Importantly, incubation of 32D ( Bcr-Ablwt ) cells with the kinase inhibitor imatinib mesylate prior to G-CSF stimulation completely neutralized the effects of Bcr-Abl on granulocytic differentiation and on C/EBPalpha and C/EBPepsilon expression